ST2 cardiac biomarker
The ST2 cardiac biomarker (also known as soluble interleukin 1 receptor-like 1) is a protein biomarker of cardiac stress encoded by the IL1RL1 gene. ST2 signals the presence and severity of adverse cardiac remodeling and tissue fibrosis, which occurs in response to myocardial infarction, acute coronary syndrome, or worsening heart failure.
| interleukin 1 receptor-like 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL1RL1 | ||||||
| NCBI gene | 9173 | ||||||
| HGNC | 5998 | ||||||
| OMIM | 601203 | ||||||
| RefSeq | NM_016232 | ||||||
| UniProt | Q01638 | ||||||
| Other data | |||||||
| Locus | Chr. 2 q12 | ||||||
| |||||||
ST2 provides prognostic information that is independent of other cardiac biomarkers such as BNP, NT-proBNP, highly sensitive troponin, GDF-15, and galectin-3. One study indicated that discrimination is independent of age, body mass index, history of heart failure, anemia and impaired kidney function or sex.
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