Galectin-3

LGALS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A3K, 1KJL, 1KJR, 2NMN, 2NMO, 2NN8, 2XG3, 3AYA, 3AYC, 3AYD, 3AYE, 3T1L, 3T1M, 3ZSJ, 3ZSK, 3ZSL, 3ZSM, 4BLI, 4BLJ, 4BM8, 4JC1, 4JCK, 4LBJ, 4LBK, 4LBL, 4LBM, 4LBN, 4LBO, 4R9A, 4R9B, 4R9C, 4R9D, 4RL7, 4XBN, 5H9R, 5H9P
Identifiers
Aliases	LGALS3, CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2, lectin, galactoside binding soluble 3, galectin 3
External IDs	OMIM: 153619 MGI: 96778 HomoloGene: 37608 GeneCards: LGALS3
Gene location (Human)
Chr.	Chromosome 14 (human)
End	55,145,423 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	47,623,617 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; bronchial epithelial cell; ; jejunal mucosa; ; amniotic fluid; ; visceral pleura; ; lactiferous duct; ; trachea; ; duodenum; ; parotid gland; ; urethra;
	Top expressed in
	left colon; ; calvaria; ; lip; ; skin of abdomen; ; skin of back; ; pyloric antrum; ; corneal stroma; ; right lung lobe; ; superior surface of tongue; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; chemoattractant activity; IgE binding; laminin binding; carbohydrate binding; RNA binding; oligosaccharide binding; protein phosphatase inhibitor activity; protein phosphatase binding;
Cellular component	cytoplasm; membrane; extracellular matrix; plasma membrane; immunological synapse; mitochondrial inner membrane; spliceosomal complex; extracellular exosome; nucleus; extracellular space; secretory granule membrane; ficolin-1-rich granule membrane; galectin complex; extracellular region; cell surface; collagen-containing extracellular matrix;
Biological process	negative regulation of endocytosis; cell differentiation; regulation of T cell proliferation; negative regulation of immunological synapse formation; epithelial cell differentiation; monocyte chemotaxis; immune system process; mRNA processing; eosinophil chemotaxis; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of mononuclear cell migration; neutrophil chemotaxis; negative regulation of T cell receptor signaling pathway; mononuclear cell migration; positive regulation of calcium ion import; macrophage chemotaxis; regulation of T cell apoptotic process; RNA splicing; positive regulation of dendritic cell differentiation; regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; positive chemotaxis; innate immune response; neutrophil degranulation; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of myeloid cell differentiation; positive regulation of protein homodimerization activity; positive regulation of protein localization to plasma membrane; negative regulation of protein tyrosine phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	3958
	16854
	ENSG00000131981
	ENSMUSG00000050335
	P17931
	P16110
	NM_001177388; NM_002306; NM_001357678
	NM_001145953; NM_010705
	NP_002297; NP_001344607
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Galectin-3 is a protein that in humans is encoded by the LGALS3 gene. Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified.

Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition-binding domain (CRD) of about 130 amino acids that enable the specific binding of β-galactosides.

Galectin-3 (Gal-3) is also a member of the beta-galactoside-binding protein family that plays an important role in cell-cell adhesion, cell-matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis.

Galectin-3 is encoded by a single gene, LGALS3, located on chromosome 14, locus q21–q22. Galectin-3 is expressed in the nucleus, cytoplasm, mitochondrion, cell surface, and extracellular space.

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