SEMA7A

SEMA7A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3NVQ
Identifiers
Aliases	SEMA7A, CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL, semaphorin 7A (John Milton Hagen blood group), PFIC11
External IDs	OMIM: 607961 MGI: 1306826 HomoloGene: 2678 GeneCards: SEMA7A
Gene location (Human)
Chr.	Chromosome 15 (human)
End	74,433,958 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	57,870,148 bp
RNA expression pattern
	Top expressed in
	spleen; ; placenta; ; prefrontal cortex; ; stromal cell of endometrium; ; superior frontal gyrus; ; Brodmann area 9; ; lymph node; ; tibial nerve; ; substantia nigra; ; appendix;
	Top expressed in
	cumulus cell; ; cerebellar cortex; ; superior frontal gyrus; ; anterior horn of spinal cord; ; primary motor cortex; ; lateral geniculate nucleus; ; cerebellar vermis; ; barrel cortex; ; pontine nuclei; ; inferior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; integrin binding; neuropilin binding; semaphorin receptor binding; chemorepellent activity;
Cellular component	membrane; plasma membrane; anchored component of membrane; extracellular space; external side of plasma membrane; integral component of plasma membrane; collagen-containing extracellular matrix;
Biological process	cell differentiation; positive regulation of protein phosphorylation; nervous system development; multicellular organism development; osteoblast differentiation; immune response; positive regulation of ERK1 and ERK2 cascade; axon extension; olfactory lobe development; integrin-mediated signaling pathway; positive regulation of axon extension; inflammatory response; neuron projection development; regulation of inflammatory response; negative chemotaxis; positive regulation of macrophage cytokine production; neural crest cell migration; positive regulation of cell migration; negative regulation of axon extension involved in axon guidance; semaphorin-plexin signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8482
	20361
	ENSG00000138623; ENSG00000288455
	ENSMUSG00000038264
	O75326
	Q9QUR8
	NM_003612; NM_001146029; NM_001146030
	NM_011352
	NP_001139501; NP_001139502; NP_003603
	NP_035482
	Wikidata
View/Edit Human	View/Edit Mouse

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.

SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM] SEMA7A is expressed in various adult tissues such as adipose, colon, esophagus, heart, brain, spleen, testis, lung, ovary, and uterus.

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