Transforming protein RhoA

RHOA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5BWM, 1A2B, 1CC0, 1CXZ, 1DPF, 1FTN, 1KMQ, 1LB1, 1OW3, 1S1C, 1TX4, 1X86, 1XCG, 2RGN, 3KZ1, 3LW8, 3LWN, 3LXR, 3MSX, 3T06, 4D0N, 4XH9, 4XSG, 4XSH, 4XOI, 5A0F, 5FR2, 5FR1, 5JCP, 5C2K, 5C4M, 5HPY
Identifiers
Aliases	RHOA, ARH12, ARHA, RHO12, RHOH12, ras homolog family member A, EDFAOB
External IDs	OMIM: 165390 MGI: 1096342 HomoloGene: 68986 GeneCards: RHOA
Gene location (Human)
Chr.	Chromosome 3 (human)
End	49,412,998 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	108,215,133 bp
RNA expression pattern
	Top expressed in
	monocyte; ; popliteal artery; ; synovial joint; ; thymus; ; right lung; ; spongy bone; ; left coronary artery; ; right coronary artery; ; smooth muscle tissue; ; ascending aorta;
	Top expressed in
	seminal vesicula; ; ascending aorta; ; aortic valve; ; left lung lobe; ; thymus; ; dermis; ; belly cord; ; right lung; ; molar; ; uterus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; myosin binding; GTP binding; protein binding; GTPase activity; GDP binding; protein kinase binding; protein domain specific binding; Rho GDP-dissociation inhibitor binding;
Cellular component	cytoplasm; vesicle; cytosol; endosome; cell projection; endoplasmic reticulum membrane; membrane; focal adhesion; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; cell junction; cell cortex; midbody; cleavage furrow; cytoskeleton; apical junction complex; extracellular exosome; cell periphery; lamellipodium; secretory granule membrane; ficolin-1-rich granule membrane; nucleus; axon; cell division site; ruffle membrane; dendritic spine; intracellular membrane-bounded organelle; postsynapse; glutamatergic synapse; intracellular anatomical structure;
Biological process	actin cytoskeleton reorganization; ossification involved in bone maturation; apolipoprotein A-I-mediated signaling pathway; regulation of cell migration; negative chemotaxis; regulation of actin cytoskeleton organization; cleavage furrow formation; substantia nigra development; ephrin receptor signaling pathway; endothelial tube lumen extension; Roundabout signaling pathway; positive regulation of axonogenesis; stress fiber assembly; positive regulation of lipase activity; regulation of osteoblast proliferation; cell division; positive regulation of cytokinesis; platelet activation; negative regulation of cell migration involved in sprouting angiogenesis; positive regulation of protein serine/threonine kinase activity; mitotic cleavage furrow formation; mitotic spindle assembly; negative regulation of axonogenesis; vascular endothelial growth factor receptor signaling pathway; skeletal muscle satellite cell migration; trabecula morphogenesis; positive regulation of neuron differentiation; Rho protein signal transduction; positive regulation of I-kappaB kinase/NF-kappaB signaling; cell cycle; viral process; regulation of small GTPase mediated signal transduction; transforming growth factor beta receptor signaling pathway; cell migration; apical junction assembly; wound healing, spreading of cells; endothelial cell migration; positive regulation of stress fiber assembly; actin cytoskeleton organization; phosphatidylinositol-mediated signaling; small GTPase mediated signal transduction; regulation of cell motility; Wnt signaling pathway, planar cell polarity pathway; protein deubiquitination; neutrophil degranulation; cell morphogenesis; response to hypoxia; angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure; alpha-beta T cell lineage commitment; regulation of systemic arterial blood pressure by endothelin; regulation of transcription by RNA polymerase II; cytoskeleton organization; actin filament organization; cell adhesion; cell-matrix adhesion; G protein-coupled receptor signaling pathway; skeletal muscle tissue development; regulation of actin polymerization or depolymerization; regulation of cell shape; response to mechanical stimulus; response to glucose; negative regulation of cell-substrate adhesion; regulation of neuron projection development; negative regulation of neuron projection development; cerebral cortex cell migration; forebrain radial glial cell differentiation; cell differentiation; positive regulation of cell growth; positive regulation of cell migration; androgen receptor signaling pathway; positive regulation of actin filament polymerization; establishment or maintenance of actin cytoskeleton polarity; stress-activated protein kinase signaling cascade; negative regulation of intracellular steroid hormone receptor signaling pathway; cell junction assembly; odontogenesis; negative regulation of I-kappaB kinase/NF-kappaB signaling; response to amino acid; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; beta selection; negative regulation of neuron apoptotic process; positive regulation of neuron apoptotic process; establishment of epithelial cell apical/basal polarity; response to ethanol; negative regulation of neuron differentiation; positive regulation of translation; positive regulation of cell adhesion; negative regulation of cell size; positive regulation of vasoconstriction; positive regulation of smooth muscle contraction; GTP metabolic process; positive regulation of alpha-beta T cell differentiation; neuron projection morphogenesis; regulation of dendrite development; actin filament bundle assembly; response to glucocorticoid; regulation of focal adhesion assembly; regulation of calcium ion transport; negative regulation of cell death; regulation of microtubule cytoskeleton organization; cellular response to lipopolysaccharide; cellular response to cytokine stimulus; positive regulation of podosome assembly; negative regulation of oxidative phosphorylation; positive regulation of NIK/NF-kappaB signaling; negative regulation of reactive oxygen species biosynthetic process; positive regulation of vascular associated smooth muscle contraction; positive regulation of leukocyte adhesion to vascular endothelial cell; regulation of modification of synaptic structure; regulation of modification of postsynaptic actin cytoskeleton; cellular response to chemokine; regulation of neural precursor cell proliferation; positive regulation of T cell migration;
	Sources:Amigo / QuickGO
Orthologs
	387
	11848
	ENSG00000067560
	ENSMUSG00000007815
	P61586
	Q9QUI0
NM_001313941; NM_001313943; NM_001313944; NM_001313945; NM_001313946;
	NM_001313947; NM_001664
	NM_016802; NM_001313961; NM_001313962
NP_001300870; NP_001300872; NP_001300873; NP_001300874; NP_001300875;
	NP_001300876; NP_001655; NP_001300870.1; NP_001655.1
	NP_001300890; NP_001300891; NP_058082
	Wikidata
View/Edit Human	View/Edit Mouse

Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the RHOA gene. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. It acts upon several effectors. Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in Drosophila) are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billion years. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evolution. RhoA specifically is regarded as a prominent regulatory factor in other functions such as the regulation of cytoskeletal dynamics, transcription, cell cycle progression and cell transformation.

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