ROCK1

ROCK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S1C, 2ESM, 2ETK, 2ETR, 2V55, 3D9V, 3NCZ, 3NDM, 3O0Z, 3TV7, 3TWJ, 3V8S, 4L2W, 4W7P, 4YVC, 4YVE, 5BML
Identifiers
Aliases	ROCK1, P160ROCK, ROCK-I, Rho associated coiled-coil containing protein kinase 1
External IDs	OMIM: 601702 MGI: 107927 HomoloGene: 55899 GeneCards: ROCK1
Gene location (Human)
Chr.	Chromosome 18 (human)
End	21,111,813 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	10,182,045 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; popliteal artery; ; monocyte; ; right coronary artery; ; bone marrow cells; ; left coronary artery; ; ascending aorta; ; gastric mucosa; ; right lung; ; smooth muscle tissue;
	Top expressed in
	secondary oocyte; ; ciliary body; ; ascending aorta; ; lacrimal gland; ; aortic valve; ; left lung lobe; ; blood; ; cumulus cell; ; iris; ; otic placode;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; tau protein binding; tau-protein kinase activity; Rho-dependent protein serine/threonine kinase activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; cell projection; membrane; ruffle; Golgi membrane; plasma membrane; bleb; centriole; cytoskeleton; lamellipodium; extracellular region; secretory granule lumen; cytoplasmic stress granule; amyloid-beta complex;
Biological process	negative regulation of neuron apoptotic process; leukocyte cell-cell adhesion; smooth muscle contraction; myoblast migration; intracellular signal transduction; regulation of actin cytoskeleton organization; phosphorylation; ephrin receptor signaling pathway; bleb assembly; negative regulation of protein binding; regulation of actin filament-based process; regulation of stress fiber assembly; regulation of cell motility; protein phosphorylation; negative regulation of bicellular tight junction assembly; vascular endothelial growth factor receptor signaling pathway; regulation of cell adhesion; Rho protein signal transduction; membrane to membrane docking; leukocyte tethering or rolling; regulation of focal adhesion assembly; negative regulation of angiogenesis; regulation of keratinocyte differentiation; positive regulation of focal adhesion assembly; negative regulation of myosin-light-chain-phosphatase activity; I-kappaB kinase/NF-kappaB signaling; regulation of establishment of cell polarity; cortical actin cytoskeleton organization; apical constriction; regulation of establishment of endothelial barrier; actin cytoskeleton organization; leukocyte migration; signal transduction; regulation of cytoskeleton organization; apoptotic process; neutrophil degranulation; execution phase of apoptosis; protein localization to plasma membrane; G protein-coupled receptor signaling pathway; aortic valve morphogenesis; regulation of autophagy; positive regulation of autophagy; positive regulation of cardiac muscle hypertrophy; positive regulation of gene expression; peptidyl-serine phosphorylation; neuron projection development; positive regulation of MAPK cascade; regulation of neuron differentiation; negative regulation of membrane protein ectodomain proteolysis; negative regulation of biomineral tissue development; response to transforming growth factor beta; regulation of angiotensin-activated signaling pathway; neuron projection arborization; positive regulation of amyloid-beta clearance; regulation of synaptic vesicle endocytosis; regulation of amyloid-beta formation; negative regulation of amyloid-beta formation; negative regulation of amyloid precursor protein catabolic process; positive regulation of connective tissue replacement; response to angiotensin; mRNA destabilization; blood vessel diameter maintenance; mitotic cytokinesis; peptidyl-threonine phosphorylation; actomyosin structure organization; embryonic morphogenesis; regulation of cell junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	6093
	19877
	ENSG00000067900
	ENSMUSG00000024290
	Q13464
	P70335
	NM_005406
	NM_009071
	NP_005397
	NP_033097
	Wikidata
View/Edit Human	View/Edit Mouse

ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common names are ROKβ and P160ROCK. ROCK1 is a major downstream effector of the small GTPase RhoA and is a regulator of the actomyosin cytoskeleton which promotes contractile force generation. ROCK1 plays a role in cancer and in particular cell motility, metastasis, and angiogenesis.

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