Retinoid X receptor beta

RXRB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H9U, 1UHL, 5HJP, 5I4V
Identifiers
Aliases	RXRB, DAUDI6, H-2RIIBP, NR2B2, RCoR-1, Retinoid X receptor beta, RXRbeta, RXR-beta
External IDs	OMIM: 180246 MGI: 98215 HomoloGene: 7923 GeneCards: RXRB
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,200,665 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,257,373 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; gastric mucosa; ; left lobe of thyroid gland; ; right coronary artery; ; right uterine tube; ; pituitary gland; ; canal of the cervix; ; tibial nerve; ; spleen; ; anterior pituitary;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; renal corpuscle; ; ankle; ; crypt of lieberkuhn of small intestine; ; motor neuron; ; fossa; ; ankle joint; ; condyle; ; superior frontal gyrus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription coactivator activity; zinc ion binding; metal ion binding; steroid hormone receptor activity; nuclear receptor activity; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; steroid hormone mediated signaling pathway; intracellular receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6257
	20182
ENSG00000235712; ENSG00000231321; ENSG00000227322; ENSG00000204231; ENSG00000206289;
	ENSG00000228333
	ENSMUSG00000039656
	P28702; Q5STP9
	P28704
	NM_001270401; NM_001291989; NM_021976
	NM_001205214; NM_001205215; NM_001205216; NM_011306
	NP_001257330; NP_001278918; NP_068811; NP_068811.1
	NP_001192143; NP_001192144; NP_001192145; NP_035436
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2) is a nuclear receptor that in humans is encoded by the RXRB gene.

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.

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