Vitamin D receptor

The vitamin D receptor (VDR also known as the calcitriol receptor) is a member of the nuclear receptor family of transcription factors. Calcitriol (the active form of vitamin D, 1,25-(OH)2vitamin D3) binds to VDR, which then forms a heterodimer with the retinoid-X receptor. The VDR heterodimer then enters the nucleus and binds to Vitamin D responsive elements (VDRE) in genomic DNA. VDR binding results in expression or transrepression of many specific gene products. VDR is also involved in microRNA-directed post transcriptional mechanisms. In humans, the vitamin D receptor is encoded by the VDR gene located on chromosome 12q13.11.

VDR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVDR, NR1I1, PPP1R163, vitamin D (1,25- dihydroxyvitamin D3) receptor, vitamin D receptor
External IDsOMIM: 601769 MGI: 103076 HomoloGene: 37297 GeneCards: VDR
Orthologs
SpeciesHumanMouse
Entrez

7421

22337

Ensembl

ENSG00000111424

ENSMUSG00000022479

UniProt

P11473

P48281

RefSeq (mRNA)

NM_009504

RefSeq (protein)

NP_033530

Location (UCSC)Chr 12: 47.84 – 47.94 MbChr 15: 97.75 – 97.81 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

VDR is expressed in most tissues of the body, and regulates transcription of genes involved in intestinal and renal transport of calcium and other minerals. Glucocorticoids decrease VDR expression. Many types of immune cells also express VDR.

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