RTI-229

RTI-229
Legal status
Legal status	In general: legal;
Identifiers
	IUPAC name [(1R,2S,3S,5S)-3-(4-Iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-2-yl]-pyrrolidin-1-ylmethanone;
CAS Number	160948-17-4 ;
PubChem CID	9910220;
UNII	4XC2A2NPZ2;
CompTox Dashboard (EPA)	DTXSID10432717 ;
Chemical and physical data
Formula	C19H25IN2O
Molar mass	424.326 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)C3=CC=C(C=C3)I)C(=O)N4CCCC4;
	(verify)

RTI-229, also known as (–)-3β-(4-iodophenyl)tropane-2β-pyrrolidine carboxamide and RTI-4229-229, is a potent and long-lasting stimulant drug which was developed in the 1990s as part of a large group of related analogues from the phenyltropane family. With the combination of two potent dopamine transporter (DAT) binding motifs attached to the tropane ring, the p-iodo phenyl group at the 3β-position and a pyrrolidine carboxamide at 2β, RTI-229 has extremely high selectivity for the dopamine transporter (2600x and 4600x selective over NET and 5-HTT respectively) and is one of the most DAT-selective compounds in the RTI series.

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