Dopamine transporter

SLC6A3
Identifiers
Aliases	SLC6A3, solute carrier family 6 (neurotransmitter transporter), member 3, DAT, DAT1, PKDYS, solute carrier family 6 member 3, Dopamine transporter, PKDYS1
External IDs	OMIM: 126455 MGI: 94862 HomoloGene: 55547 GeneCards: SLC6A3
Gene location (Human)
Chr.	Chromosome 5 (human)
End	1,445,440 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	73,726,791 bp
RNA expression pattern
	Top expressed in
	substantia nigra; ; left lobe of thyroid gland; ; canal of the cervix; ; right lobe of thyroid gland; ; renal cortex; ; hypothalamus; ; upper lobe of left lung; ; left uterine tube; ; vagina; ; myometrium;
	Top expressed in
	substantia nigra; ; ventral tegmental area; ; hypothalamus; ; arcuate nucleus; ; suprachiasmatic nucleus; ; olfactory bulb; ; sexually immature organism; ; tracheobronchial tree; ; median eminence; ; trachea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein N-terminus binding; dopamine:sodium symporter activity; metal ion binding; neurotransmitter:sodium symporter activity; dopamine binding; protein binding; symporter activity; monoamine transmembrane transporter activity; protein-containing complex binding; protease binding; signaling receptor binding; protein phosphatase 2A binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; cell surface; axon; flotillin complex; neuronal cell body; membrane raft; presynapse; neuron projection; dopaminergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane;
Biological process	response to cocaine; prepulse inhibition; response to organic cyclic compound; locomotory behavior; dopamine biosynthetic process; response to nicotine; human ageing; neurotransmitter biosynthetic process; monoamine transport; adenohypophysis development; regulation of dopamine metabolic process; response to iron ion; sensory perception of smell; dopamine uptake involved in synaptic transmission; dopamine catabolic process; dopamine transport; positive regulation of multicellular organism growth; response to cAMP; lactation; response to ethanol; neurotransmitter transport; dopamine uptake; transmembrane transport; neurotransmitter uptake;
	Sources:Amigo / QuickGO
Orthologs
	6531
	13162
	ENSG00000142319; ENSG00000276996
	ENSMUSG00000021609
	Q01959
	Q61327
	NM_001044
	NM_010020
	NP_001035
	NP_034150
	Wikidata
View/Edit Human	View/Edit Mouse

The dopamine transporter (DAT) also (sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in the human by the SLC6A3 gene, (also known as DAT1), that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopamine into vesicles for storage and later release. Dopamine reuptake via DAT provides the primary mechanism through which dopamine is cleared from synapses, although there may be an exception in the prefrontal cortex, where evidence points to a possibly larger role of the norepinephrine transporter.

DAT is implicated in a number of dopamine-related disorders, including attention deficit hyperactivity disorder, bipolar disorder, clinical depression, eating disorders, and substance use disorders. The gene that encodes the DAT protein is located on chromosome 5, consists of 15 coding exons, and is roughly 64 kbp long. Evidence for the associations between DAT and dopamine related disorders has come from a type of genetic polymorphism, known as a variable number tandem repeat, in the SLC6A3 gene, which influences the amount of protein expressed.

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