RAG2

RAG2
Identifiers
Aliases	RAG2, RAG-2, recombination activating gene 2, recombination activating 2
External IDs	OMIM: 179616 MGI: 97849 HomoloGene: 7507 GeneCards: RAG2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	36,598,279 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	101,462,874 bp
RNA expression pattern
	Top expressed in
	thymus; ; bone marrow; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; bone marrow cells; ; corpus callosum; ; thymus; ; muscle tissue; ; metanephros; ; corpus epididymis;
	Top expressed in
	thymus; ; bone marrow; ; heart; ; cochlea; ; exocrine gland; ; hepatobiliary system; ; liver; ; embryo; ; embryonic structure; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; ubiquitin protein ligase activity; zinc ion binding; chromatin binding; phosphatidylinositol-3,5-bisphosphate binding; metal ion binding; phosphatidylinositol-3,4-bisphosphate binding; methylated histone binding; phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-trisphosphate binding; sequence-specific DNA binding;
Cellular component	nucleoplasm; nucleus; DNA recombinase complex;
Biological process	DNA recombination; B cell homeostatic proliferation; T cell differentiation in thymus; positive regulation of organ growth; T cell differentiation; B cell lineage commitment; protein ubiquitination; V(D)J recombination; pre-B cell allelic exclusion; B cell differentiation; T cell lineage commitment; defense response to bacterium; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	5897
	19374
	ENSG00000175097
	ENSMUSG00000032864
	P55895
	P21784
	NM_000536; NM_001243785; NM_001243786
	NM_009020
	NP_000527; NP_001230714; NP_001230715
	NP_033046
	Wikidata
View/Edit Human	View/Edit Mouse

Recombination activating gene 2 protein (also known as RAG-2) is a lymphocyte-specific protein encoded by RAG2 gene on human chromosome 11. Together with RAG1 protein, RAG2 forms a V(D)J recombinase, a protein complex required for the process of V(D)J recombination during which the variable regions of immunoglobulin and T cell receptor genes are assembled in developing B and T lymphocytes. Therefore, RAG2 is essential for generation of mature B and T lymphocytes.

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