RAG1

RAG1
Identifiers
Aliases	RAG1, RAG-1, RNF74, recombination activating gene 1, recombination activating 1
External IDs	OMIM: 179615 MGI: 97848 HomoloGene: 387 GeneCards: RAG1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	36,593,156 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	101,479,846 bp
RNA expression pattern
	Top expressed in
	thymus; ; bone marrow; ; spleen; ; stromal cell of endometrium; ; bone marrow cells; ; islet of Langerhans; ; left adrenal gland; ; thyroid gland; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	Top expressed in
	thymus; ; bone marrow; ; body of femur; ; sternocleidomastoid muscle; ; inner cell mass; ; sexually immature organism; ; trachea; ; lens; ; cochlea; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein homodimerization activity; ubiquitin protein ligase activity; histone binding; zinc ion binding; metal ion binding; ubiquitin-protein transferase activity; protein binding; catalytic activity; nuclease activity; endonuclease activity; hydrolase activity; transferase activity; identical protein binding; double-stranded DNA endodeoxyribonuclease activity;
Cellular component	nucleoplasm; nucleus; DNA recombinase complex; endodeoxyribonuclease complex;
Biological process	positive regulation of T cell differentiation; histone monoubiquitination; DNA recombination; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; adaptive immune response; T cell differentiation in thymus; nucleic acid phosphodiester bond hydrolysis; thymus development; negative regulation of thymocyte apoptotic process; T cell homeostasis; negative regulation of T cell apoptotic process; immune response; V(D)J recombination; pre-B cell allelic exclusion; B cell differentiation; metabolism; regulation of T cell differentiation; protein autoubiquitination; visual learning; regulation of behavioral fear response; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	5896
	19373
	ENSG00000166349
	ENSMUSG00000061311
	P15918
	P15919
	NM_000448
	NM_009019
	NP_000439; NP_001364206; NP_001364207; NP_001364208; NP_001364209
	NP_033045
	Wikidata
View/Edit Human	View/Edit Mouse

Recombination activating gene 1 also known as RAG-1 is a protein that in humans is encoded by the RAG1 gene.

The RAG1 and RAG2 genes are largely conserved in humans. 55.99% and 55.98% of the encoded amino acids contain no reported variants, respectively.

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