Pseudomonas exotoxin
The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. Vibrio cholerae produces a similar protein called the Cholix toxin (Q5EK40).
| Exotoxin A | |||||||
|---|---|---|---|---|---|---|---|
Exotoxin A dimer, Pseudomonas aeruginosa | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | eta | ||||||
| UniProt | P11439 | ||||||
| Other data | |||||||
| EC number | 2.4.2.36 | ||||||
| |||||||
It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2 using NAD+. This then causes the elongation of polypeptides to cease. This mechanism is similar to that of diphtheria toxin.
It has been investigated as a treatment for hepatitis B and cancer.
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