EEF2

EEF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4V6X
Identifiers
Aliases	EEF2, EEF-2, EF-2, EF2, SCA26, eukaryotic translation elongation factor 2, Eukaryotic elongation factor 2
External IDs	OMIM: 130610 MGI: 95288 HomoloGene: 134867 GeneCards: EEF2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,985,463 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,018,332 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; stromal cell of endometrium; ; external globus pallidus; ; corpus epididymis; ; caput epididymis; ; Achilles tendon; ; germinal epithelium; ; lactiferous duct; ; nipple; ; cardia;
	Top expressed in
	molar; ; lacrimal gland; ; maxillary prominence; ; somite; ; ankle; ; submandibular gland; ; crypt of lieberkuhn of small intestine; ; calvaria; ; dorsal tegmental nucleus; ; medulla oblongata;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ribosome binding; GTP binding; p53 binding; translation elongation factor activity; actin filament binding; protein binding; 5S rRNA binding; protein kinase binding; RNA binding; GTPase activity; cadherin binding;
Cellular component	cytoplasm; polysome; membrane; plasma membrane; aggresome; membrane raft; extracellular exosome; nucleus; polysomal ribosome; extracellular matrix; extracellular region; cytosol; secretory granule lumen; ficolin-1-rich granule lumen; synapse; ribonucleoprotein complex;
Biological process	response to estradiol; positive regulation of cytoplasmic translation; skeletal muscle contraction; translational elongation; human ageing; positive regulation of translation; response to endoplasmic reticulum stress; cellular response to brain-derived neurotrophic factor stimulus; response to ischemia; hematopoietic progenitor cell differentiation; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; glial cell proliferation; skeletal muscle cell differentiation; response to folic acid; response to ethanol; response to hydrogen peroxide; protein biosynthesis; protein methylation; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	1938
	13629
	ENSG00000167658
	ENSMUSG00000034994
	P13639
	P58252
	NM_001961
	NM_007907
	NP_001952
	NP_031933
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic counterpart of bacterial EF-G.

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the ribosome. This protein is completely inactivated by EF-2 kinase phosphorylation.

aEF2/eEF2 found in most archaea and eukaryotes, including humans, contains a post translationally modified histidine diphthamide. It is the target of diphtheria toxin (from Corynebacterium diphtheriae), and exotoxin A (from Pseudomonas aeruginosa). The inactivation of EF-2 by toxins inhibits protein production in the host, causing symptoms due to loss of function in affected cells.

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