Protein phosphatase 2

Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. Its serine/threonine phosphatase activity has a broad substrate specificity and diverse cellular functions. Among the targets of PP2A are proteins of oncogenic signaling cascades, such as Raf, MEK, and AKT, where PP2A may act as a tumor suppressor.

"PP2" redirects here. For the kinase inhibitor, see PP2 (kinase inhibitor). For the movie, see The Pink Panther 2. For the other movie, see Pitch Perfect 2.
protein phosphatase 2, catalytic subunit, alpha isoform
The catalytic (C) subunit of protein phosphatase 2A. The protein is shown in rainbow color with the N-terminus in blue and the C-terminus in red. The methylated carboxyl group of the C-terminal leucine residue is shown in white. The purple spheres are two catalytically required manganese ions and the dark gray compound at center is a peptidomimetic toxin, microcystin, occupying the active site. From PDB: 2IAE​.
Identifiers
SymbolPPP2CA
NCBI gene5515
HGNC9299
OMIM176915
RefSeqNM_002715
UniProtP67775
Other data
EC number3.1.3.16
LocusChr. 5 q23-q31
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StructuresSwiss-model
DomainsInterPro
protein phosphatase 2, catalytic subunit, beta isoform
Identifiers
SymbolPPP2CB
NCBI gene5516
HGNC9300
OMIM176916
RefSeqNM_001009552
UniProtP62714
Other data
EC number3.1.3.16
LocusChr. 8 p12
Search for
StructuresSwiss-model
DomainsInterPro
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