c-Raf

RAF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C1Y, 1FAQ, 1FAR, 1GUA, 1RFA, 3CU8, 3IQJ, 3IQU, 3IQV, 3KUC, 3KUD, 3NKX, 3O8I, 3OMV, 4FJ3, 4G0N, 4G3X, 4IEA, 4IHL
Identifiers
Aliases	RAF1, Raf-1 proto-oncogene, serine/threonine kinase, CMD1NN, CRAF, NS5, Raf-1, c-Raf
External IDs	OMIM: 164760 MGI: 97847 HomoloGene: 48145 GeneCards: RAF1
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	115,653,596 bp
RNA expression pattern
	n/a
	Top expressed in
	epithelium of stomach; ; medullary collecting duct; ; secondary oocyte; ; ganglionic eminence; ; temporal muscle; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; medial ganglionic eminence; ; mucous cell of stomach;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; protein serine/threonine kinase activity; small GTPase binding; protein binding; identical protein binding; ATP binding; kinase activity; MAP kinase kinase kinase activity; enzyme binding; mitogen-activated protein kinase kinase binding; adenylate cyclase binding; adenylate cyclase activator activity; protein heterodimerization activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; pseudopodium; membrane; plasma membrane; mitochondrial outer membrane; mitochondrion; nucleus; nuclear speck; intracellular anatomical structure;
Biological process	response to muscle stretch; regulation of apoptotic process; cell differentiation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of protein phosphorylation; intracellular signal transduction; response to hypoxia; somatic stem cell population maintenance; phosphorylation; thymus development; cellular glucose homeostasis; negative regulation of protein-containing complex assembly; wound healing; stimulatory C-type lectin receptor signaling pathway; negative regulation of apoptotic process; MAPK cascade; positive regulation of peptidyl-serine phosphorylation; regulation of cell motility; platelet activation; protein phosphorylation; heart development; thyroid gland development; ion transmembrane transport; face development; death-inducing signaling complex assembly; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; intermediate filament cytoskeleton organization; regulation of cell differentiation; cell population proliferation; regulation of Rho protein signal transduction; signal transduction; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; insulin secretion involved in cellular response to glucose stimulus; apoptotic process; neurotrophin TRK receptor signaling pathway; multicellular organism development; negative regulation of signal transduction; positive regulation of ERK1 and ERK2 cascade; activation of adenylate cyclase activity;
	Sources:Amigo / QuickGO
Orthologs
	5894
	110157
	ENSG00000132155
	ENSMUSG00000000441
	P04049
	Q99N57
	NM_002880
	NM_029780; NM_001356333; NM_001356334
NP_002871; NP_001341618; NP_001341619; NP_001341620; NP_001341621;
	NP_001341622; NP_001341624; NP_001341623
	NP_084056; NP_001343262; NP_001343263
	Wikidata
View/Edit Human	View/Edit Mouse

RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded by the RAF1 gene. The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase (MAP3K) that functions downstream of the Ras subfamily of membrane associated GTPases. C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases, from the TKL (Tyrosine-kinase-like) group of kinases.

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