Protein Z-related protease inhibitor
Protein Z-dependent protease inhibitor (ZPI) is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. It is a member of the class of the serine protease inhibitors (serpins). Its name implies that it requires protein Z, another circulating protein, to function properly, but this only applies to its inhibition of factor X.
Crystal structure of protein Z-dependent peptidase inhibitor (red) in complex with protein Z (blue). Rendered from PDB 3F1S | |||||||
| Identifiers | |||||||
|---|---|---|---|---|---|---|---|
| Symbol | SERPINA10 | ||||||
| NCBI gene | 51156 | ||||||
| HGNC | 15996 | ||||||
| OMIM | 605271 | ||||||
| RefSeq | NM_016186 | ||||||
| UniProt | Q9UK55 | ||||||
| Other data | |||||||
| Locus | Chr. 14 q32.1 | ||||||
| |||||||
It is about 72 kDa heavy and 444 amino acids large. It is produced by the liver.
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