Protein Z

Protein Z (PZ or PROZ) is a mammalian protein which is encoded by the PROZ gene.

For other uses, see Z-gene (disambiguation).
protein Z
Crystallographic structure protein Z.
Identifiers
SymbolPROZ
NCBI gene8858
HGNC9460
OMIM176895
PDB3F1s
RefSeqNM_003891
UniProtP22891
Other data
LocusChr. 13 q34
Search for
StructuresSwiss-model
DomainsInterPro

Protein Z is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is a glycoprotein. Protein Z functions to inhibit blood coagulation by binding to an inhibitor. It is a GLA domain protein and thus Vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy.

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