Parathyroid hormone 1 receptor

PTH1R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BL1, 3C4M, 3H3G, 3L2J, 4Z8J
Identifiers
Aliases	PTH1R, PFE, PTHR, PTHR1, Parathyroid hormone 1 receptor, EKNS
External IDs	OMIM: 168468 MGI: 97801 HomoloGene: 267 GeneCards: PTH1R
Gene location (Human)
Chr.	Chromosome 3 (human)
End	46,903,799 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	110,747,145 bp
RNA expression pattern
	Top expressed in
	kidney; ; tibia; ; right lobe of liver; ; periodontal fiber; ; metanephric glomerulus; ; right lung; ; kidney tubule; ; renal medulla; ; spleen; ; canal of the cervix;
	Top expressed in
	proximal tubule; ; kidney; ; body of femur; ; calvaria; ; clavicle; ; dermis; ; internal carotid artery; ; membranous bone; ; ankle; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; parathyroid hormone receptor activity; signal transducer activity; protein self-association; peptide hormone binding; protein binding; transmembrane signaling receptor activity; protein homodimerization activity; G protein-coupled peptide receptor activity;
Cellular component	cytoplasm; integral component of membrane; membrane; receptor complex; plasma membrane; intracellular anatomical structure; brush border membrane; basolateral plasma membrane; apical plasma membrane; nucleus; integral component of plasma membrane;
Biological process	skeletal system development; G protein-coupled receptor signaling pathway; bone mineralization; chondrocyte differentiation; ossification; positive regulation of inositol phosphate biosynthetic process; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; human ageing; cellular calcium ion homeostasis; cell maturation; bone resorption; phospholipase C-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; positive regulation of cell population proliferation; osteoblast development; signal transduction; negative regulation of cell population proliferation; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5745
	19228
	ENSG00000160801
	ENSMUSG00000032492
	Q03431
	P41593
	NM_000316; NM_001184744
	NM_001083935; NM_001083936; NM_011199
	NP_000307; NP_001171673
	NP_001077404; NP_001077405; NP_035329
	Wikidata
View/Edit Human	View/Edit Mouse

Parathyroid hormone/parathyroid hormone-related peptide receptor, also known as parathyroid hormone 1 receptor (PTH1R), is a protein that in humans is encoded by the PTH1R gene. PTH1R functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP), also called parathyroid hormone-like hormone (PTHLH).

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