Parathyroid hormone-related protein

PTHLH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3H3G, 1BZG, 1M5N, 3FFD
Identifiers
Aliases	PTHLH, BDE2, HHM, PLP, PTHR, PTHRP, parathyroid hormone-like hormone, parathyroid hormone like hormone
External IDs	OMIM: 168470 MGI: 97800 HomoloGene: 2113 GeneCards: PTHLH
Gene location (Human)
Chr.	Chromosome 12 (human)
End	27,972,733 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	147,165,681 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; stromal cell of endometrium; ; canal of the cervix; ; endothelial cell; ; vagina; ; ascending aorta; ; gallbladder; ; prefrontal cortex; ; cingulate gyrus; ; minor salivary gland;
	Top expressed in
	lip; ; semi-lunar valve; ; ankle; ; hair follicle; ; epithelium of stomach; ; corneal stroma; ; aortic valve; ; extraocular muscle; ; sciatic nerve; ; ascending aorta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptide hormone receptor binding; hormone activity; protein binding;
Cellular component	extracellular region; nucleus; Golgi apparatus; nucleoplasm; extracellular space; cytoplasm; cytosol;
Biological process	regulation of gene expression; skeletal system development; osteoblast development; cell-cell signaling; female pregnancy; negative regulation of chondrocyte differentiation; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP metabolic process; positive regulation of cell population proliferation; negative regulation of cell population proliferation; epidermis development; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; bone mineralization; negative regulation of chondrocyte development;
	Sources:Amigo / QuickGO
Orthologs
	5744
	19227
	ENSG00000087494
	ENSMUSG00000048776
	P12272
	P22858
	NM_002820; NM_198964; NM_198965; NM_198966
	NM_008970
	NP_002811; NP_945315; NP_945316; NP_945317
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Parathyroid hormone-related protein (PTHrP) is a proteinaceous hormone and a member of the parathyroid hormone family secreted by mesenchymal stem cells. It is occasionally secreted by cancer cells (for example, breast cancer, certain types of lung cancer including squamous-cell lung carcinoma). However, it also has normal functions in bone, teeth, vascular tissues and other tissues.

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