Platelet-derived growth factor receptor
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGF-R, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes.
| Platelet-derived growth factor receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Ribbon image of two molecules of human PDGF receptor beta (yellow and magenta) in complex with dimeric PDGF-B (cyan and green). | |||||||||
| Identifiers | |||||||||
| Symbol | PDGFR | ||||||||
| Pfam | PF04692 | ||||||||
| InterPro | IPR006782 | ||||||||
| Membranome | 1204 | ||||||||
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| platelet-derived growth factor receptor, alpha polypeptide | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PDGFRA | ||||||
| NCBI gene | 5156 | ||||||
| HGNC | 8803 | ||||||
| OMIM | 173490 | ||||||
| RefSeq | NM_006206 | ||||||
| UniProt | P16234 | ||||||
| Other data | |||||||
| Locus | Chr. 4 q12 | ||||||
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| platelet-derived growth factor receptor, beta polypeptide | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PDGFRB | ||||||
| Alt. symbols | PDGFR | ||||||
| NCBI gene | 5159 | ||||||
| HGNC | 8804 | ||||||
| OMIM | 173410 | ||||||
| RefSeq | NM_002609 | ||||||
| UniProt | P09619 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q31-q32 | ||||||
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