PDGFA

PDGFA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MJK
Identifiers
Aliases	PDGFA, PDGF-A, PDGF1, platelet derived growth factor subunit A
External IDs	OMIM: 173430 MGI: 97527 HomoloGene: 32055 GeneCards: PDGFA
Gene location (Human)
Chr.	Chromosome 7 (human)
End	520,296 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	138,983,125 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; right coronary artery; ; body of pancreas; ; popliteal artery; ; left coronary artery; ; optic nerve; ; body of stomach; ; middle temporal gyrus; ; olfactory bulb; ; left uterine tube;
	Top expressed in
	calvaria; ; entorhinal cortex; ; iris; ; retinal pigment epithelium; ; tongue; ; internal carotid artery; ; ciliary body; ; external carotid artery; ; right lung lobe; ; corneal stroma;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	collagen binding; protein homodimerization activity; platelet-derived growth factor receptor binding; protein binding; platelet-derived growth factor binding; protein heterodimerization activity; growth factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; identical protein binding;
Cellular component	endoplasmic reticulum lumen; membrane; Golgi membrane; extracellular region; microvillus; cell surface; platelet alpha granule lumen; extracellular space; Golgi lumen;
Biological process	hair follicle development; embryonic lung development; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; negative chemotaxis; regulation of actin cytoskeleton organization; positive regulation of MAP kinase activity; regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling; positive regulation of cell migration; positive regulation of fibroblast proliferation; cell-cell signaling; platelet degranulation; extracellular matrix organization; regulation of DNA biosynthetic process; cell activation; MAPK cascade; negative regulation of platelet activation; multicellular organism development; positive regulation of mesenchymal cell proliferation; response to wounding; cell projection assembly; negative regulation of phosphatidylinositol biosynthetic process; angiogenesis; positive regulation of protein autophosphorylation; positive regulation of ERK1 and ERK2 cascade; regulation of smooth muscle cell migration; animal organ morphogenesis; positive regulation of phosphatidylinositol 3-kinase signaling; platelet-derived growth factor receptor signaling pathway; lung alveolus development; positive regulation of cell division; actin cytoskeleton organization; positive regulation of MAPK cascade; skin development; regulation of glomerular mesangial cell proliferation; regulation of peptidyl-tyrosine phosphorylation; wound healing; phosphatidylinositol phosphate biosynthetic process; positive regulation of cell population proliferation; regulation of signaling receptor activity; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	5154
	18590
	ENSG00000197461
	ENSMUSG00000025856
	P04085
	P20033
NM_002607; NM_033023; NM_001395363; NM_001395364; NM_001395365;
	NM_001395366
	NM_008808; NM_001363271
	NP_002598; NP_148983
	NP_032834; NP_001350200
	Wikidata
View/Edit Human	View/Edit Mouse

Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene.

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.

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