PAX3

PAX3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CMY
Identifiers
Aliases	PAX3, CDHS, HUP2, WS1, WS3, Pax3, paired box 3, PAX-3
External IDs	OMIM: 606597 MGI: 97487 HomoloGene: 22494 GeneCards: PAX3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	222,298,998 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	78,173,771 bp
RNA expression pattern
	Top expressed in
	minor salivary gland; ; Achilles tendon; ; gastrocnemius muscle; ; deltoid muscle; ; skin of abdomen; ; tibialis anterior muscle; ; retinal pigment epithelium; ; sperm; ; inferior ganglion of vagus nerve; ; trigeminal ganglion;
	Top expressed in
	maxillary prominence; ; pretectal area; ; female urethra; ; pineal gland; ; iris; ; lower lip; ; upper lip; ; stria vascularis; ; trigeminal ganglion; ; hair follicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	HMG box domain binding; DNA binding; protein binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	animal organ morphogenesis; positive regulation of transcription, DNA-templated; multicellular organism development; muscle organ development; regulation of transcription, DNA-templated; transcription by RNA polymerase II; sensory perception of sound; transcription, DNA-templated; nervous system development; positive regulation of transcription by RNA polymerase II; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	5077
	18505
	ENSG00000135903
	ENSMUSG00000004872
	P23760
	P24610
NM_000438; NM_001127366; NM_013942; NM_181457; NM_181458;
	NM_181459; NM_181460; NM_181461
	NM_001159520; NM_008781
NP_000429; NP_001120838; NP_039230; NP_852122; NP_852123;
	NP_852124; NP_852125; NP_852126; NP_852122.1
	NP_001152992; NP_032807
	Wikidata
View/Edit Human	View/Edit Mouse

The PAX3 (paired box gene 3) gene encodes a member of the paired box or PAX family of transcription factors. The PAX family consists of nine human (PAX1-PAX9) and nine mouse (Pax1-Pax9) members arranged into four subfamilies. Human PAX3 and mouse Pax3 are present in a subfamily along with the highly homologous human PAX7 and mouse Pax7 genes. The human PAX3 gene is located in the 2q36.1 chromosomal region, and contains 10 exons within a 100 kb region.

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