Osteoprotegerin

TNFRSF11B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3URF
Identifiers
Aliases	TNFRSF11B, OCIF, OPG, PDB5, TR1, tumor necrosis factor receptor superfamily member 11b, TNF receptor superfamily member 11b
External IDs	OMIM: 602643 MGI: 109587 HomoloGene: 1912 GeneCards: TNFRSF11B
Gene location (Human)
Chr.	Chromosome 8 (human)
End	118,951,885 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	54,141,880 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; right coronary artery; ; stromal cell of endometrium; ; Achilles tendon; ; left coronary artery; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; popliteal artery; ; tibia; ; synovial joint;
	Top expressed in
	calvaria; ; intercostal muscle; ; stria vascularis; ; cochlea; ; adrenal gland; ; abdominal aorta; ; left lung lobe; ; ankle; ; uterus; ; ascending aorta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine activity; tumor necrosis factor-activated receptor activity; protein binding; signaling receptor activity;
Cellular component	plasma membrane; integral component of plasma membrane; extracellular region; extracellular space; extracellular matrix;
Biological process	regulation of apoptotic process; skeletal system development; negative regulation of odontogenesis of dentin-containing tooth; response to nutrient; extracellular matrix organization; response to magnesium ion; tumor necrosis factor-mediated signaling pathway; response to arsenic-containing substance; response to estrogen; response to lipopolysaccharide; regulation of cell population proliferation; immune response; response to inorganic substance; apoptotic signaling pathway; inflammatory response; signal transduction; negative regulation of bone resorption; apoptotic process; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	4982
	18383
	ENSG00000164761
	ENSMUSG00000063727
	O00300
	O08712
	NM_002546
	NM_008764
	NP_002537
	NP_032790
	Wikidata
View/Edit Human	View/Edit Mouse

Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF) or tumour necrosis factor receptor superfamily member 11B (TNFRSF11B), is a cytokine receptor of the tumour necrosis factor (TNF) receptor superfamily encoded by the TNFRSF11B gene.

OPG was first discovered as a novel secreted TNFR related protein that played a role in the regulation of bone density and later for its role as a decoy receptor for receptor activator of nuclear factor kappa-B ligand (RANKL). OPG also binds to TNF-related apoptosis-inducing ligand (TRAIL) and inhibits TRAIL induced apoptosis of specific cells, including tumour cells. Other OPG ligands include syndecan-1, glycosaminoglycans, von Willebrand factor, and factor VIII-von Willebrand factor complex.

OPG has been identified as having a role in tumour growth and metastasis, heart disease, immune system development and signalling, mental health, diabetes, and the prevention of pre-eclampsia and osteoporosis during pregnancy.

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