Oct-4

POU5F1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OCP, 3L1P
Identifiers
Aliases	POU5F1, OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4, POU class 5 homeobox 1, Oct3/4
External IDs	OMIM: 164177 MGI: 101893 HomoloGene: 8422 GeneCards: POU5F1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,180,731 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,821,669 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; endometrium; ; kidney; ; body of pancreas; ; body of stomach; ; left uterine tube; ; fundus; ; right lobe of liver; ; duodenum; ; gallbladder;
	Top expressed in
	morula; ; inner cell mass; ; primitive streak; ; ooblast; ; blastocyst; ; rete testis; ; secondary oocyte; ; Hindgut; ; mesoderm; ; seminiferous tubule;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; miRNA binding; DNA-binding transcription factor activity; transcription factor binding; transcription cis-regulatory region binding; protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; ubiquitin protein ligase binding; RNA binding;
Cellular component	cytoplasm; cytosol; transcription regulator complex; nucleoplasm; nucleus; mitochondrion;
Biological process	regulation of transcription, DNA-templated; somatic stem cell population maintenance; negative regulation of gene silencing by miRNA; cell fate commitment involved in formation of primary germ layer; endodermal cell fate specification; anatomical structure morphogenesis; mRNA transcription by RNA polymerase II; regulation of asymmetric cell division; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; regulation of DNA methylation-dependent heterochromatin assembly; multicellular organism development; cardiac cell fate determination; response to wounding; BMP signaling pathway involved in heart induction; regulation of gene expression; regulation of heart induction by regulation of canonical Wnt signaling pathway; blastocyst development; positive regulation of transcription by RNA polymerase II; positive regulation of SMAD protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5460
	18999
ENSG00000230336; ENSG00000206454; ENSG00000204531; ENSG00000237582; ENSG00000229094;
	ENSG00000233911; ENSG00000235068
	ENSMUSG00000024406
	Q01860
	P20263
	NM_203289; NM_001173531; NM_001285986; NM_001285987; NM_002701
	NM_001252452; NM_013633
NP_001167002; NP_001272915; NP_001272916; NP_002692; NP_976034;
	NP_001272915.1
	NP_001239381; NP_038661
	Wikidata
View/Edit Human	View/Edit Mouse

Oct-4 (octamer-binding transcription factor 4), also known as POU5F1 (POU domain, class 5, transcription factor 1), is a protein that in humans is encoded by the POU5F1 gene. Oct-4 is a homeodomain transcription factor of the POU family. It is critically involved in the self-renewal of undifferentiated embryonic stem cells. As such, it is frequently used as a marker for undifferentiated cells. Oct-4 expression must be closely regulated; too much or too little will cause differentiation of the cells.

Octamer-binding transcription factor 4, OCT-4, is a transcription factor protein that is encoded by the POU5F1 gene and is part of the POU (Pit-Oct-Unc) family. OCT-4 consists of an octamer motif, a particular DNA sequence of AGTCAAAT that binds to their target genes and activates or deactivates certain expressions. These gene expressions then lead to phenotypic changes in stem cell differentiation during the development of a mammalian embryo. It plays a vital role in determining the fates of both inner mass cells and embryonic stem cells and has the ability to maintain pluripotency throughout embryonic development. Recently, it has been noted that OCT-4 not only maintains pluripotency in embryonic cells but also has the ability to regulate cancer cell proliferation and can be found in various cancers such as pancreatic, lung, liver and testicular germ cell tumors in adult germ cells. Another defect this gene can have is dysplastic growth in epithelial tissues which are caused by a lack of OCT-4 within the epithelial cells.

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