OSI-7904

OSI-7904
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name (2S)-2-[6-[(3-Methyl-1-oxo-2H-benzo[f]quinazolin-9-yl)methylamino]-3-oxo-1H-isoindol-2-yl]pentanedioic acid;
CAS Number	139987-54-5;
PubChem CID	135403832;
UNII	ON177ZCE7M;
CompTox Dashboard (EPA)	DTXSID70930683 ;
Chemical and physical data
Formula	C27H24N4O6
Molar mass	500.511 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=NC2=C(C3=C(C=CC(=C3)CNC4=CC5=C(C=C4)C(=O)N(C5)[C@@H](CCC(=O)O)C(=O)O)C=C2)C(=O)N1;

OSI-7904 is a noncompetitive liposomal thymidylate synthase inhibitor. OSI-7904 is a benzoquinazoline folate analog with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication.

OSI-7904L is a liposome-encapsulated formulation of OSI-7904. Liposome encapsulation improves the efficacy and increases the half-life of OSI-7904.

Its effect on solid tumors is currently under evaluation.

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