Thymidylate synthase
Thymidylate synthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage.
| thymidylate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Thymidylate synthase homodimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 2.1.1.45 | ||||||||
| CAS no. | 9031-61-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Thymidylate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Thymidylat_synt | ||||||||
| Pfam | PF00303 | ||||||||
| InterPro | IPR000398 | ||||||||
| PROSITE | PDOC00086 | ||||||||
| SCOP2 | 1tys / SCOPe / SUPFAM | ||||||||
| |||||||||
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.