Na–K–Cl cotransporter
The Na–K–Cl cotransporter (NKCC) is a transport protein that aids in the secondary active transport of sodium, potassium, and chloride into cells. In humans there are two isoforms of this membrane transport protein, NKCC1 and NKCC2, encoded by two different genes (SLC12A2 and SLC12A1 respectively). Two isoforms of the NKCC1/Slc12a2 gene result from keeping (isoform 1) or skipping (isoform 2) exon 21 in the final gene product.
| solute carrier family 12 member 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SLC12A1 | ||||||
| Alt. symbols | NKCC2 | ||||||
| NCBI gene | 6557 | ||||||
| HGNC | 10910 | ||||||
| OMIM | 600839 | ||||||
| Orthologs | 286 | ||||||
| RefSeq | NM_000338 | ||||||
| UniProt | Q13621 | ||||||
| Other data | |||||||
| Locus | Chr. 15 q21.1 | ||||||
| |||||||
| solute carrier family 12 member 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SLC12A2 | ||||||
| Alt. symbols | NKCC1 | ||||||
| NCBI gene | 6558 | ||||||
| HGNC | 10911 | ||||||
| OMIM | 600840 | ||||||
| Orthologs | 20283 | ||||||
| RefSeq | NM_001046 | ||||||
| UniProt | P55011 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q23.3 | ||||||
| |||||||
NKCC1 is widely distributed throughout the human body; it has important functions in organs that secrete fluids. It is found specifically in the kidney, where it extracts sodium, potassium, and chloride from the urine so they can be reabsorbed into the blood.
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