NFE2L2

NFE2L2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FLU, 2LZ1, 3ZGC, 4IFL
Identifiers
Aliases	NFE2L2, NRF2, HEBP1, nuclear factor, erythroid 2 like 2, IMDDHH, Nrf-2, NFE2 like bZIP transcription factor 2
External IDs	OMIM: 600492 MGI: 108420 HomoloGene: 2412 GeneCards: NFE2L2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	177,392,697 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	75,534,985 bp
RNA expression pattern
	Top expressed in
	cavity of mouth; ; bronchial epithelial cell; ; pylorus; ; cardia; ; pericardium; ; human penis; ; jejunal mucosa; ; germinal epithelium; ; gums; ; vulva;
	Top expressed in
	epithelium of stomach; ; mucous cell of stomach; ; pyloric antrum; ; left lung lobe; ; esophagus; ; duodenum; ; respiratory epithelium; ; olfactory epithelium; ; large intestine; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; protein domain specific binding; DNA-binding transcription factor activity; transcription cis-regulatory region binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; transcription coregulator binding; transcription factor binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; cytosol; centrosome; plasma membrane; protein-DNA complex; chromatin; nucleus; nucleoplasm; Golgi apparatus;
Biological process	positive regulation of glucose import; negative regulation of endothelial cell apoptotic process; negative regulation of hematopoietic stem cell differentiation; regulation of embryonic development; cellular response to glucose starvation; regulation of transcription, DNA-templated; cellular response to laminar fluid shear stress; positive regulation of transcription from RNA polymerase II promoter in response to stress; cellular response to tumor necrosis factor; proteasomal ubiquitin-independent protein catabolic process; negative regulation of cell death; cellular response to fluid shear stress; cell redox homeostasis; PERK-mediated unfolded protein response; positive regulation of glutathione biosynthetic process; transcription, DNA-templated; response to endoplasmic reticulum stress; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; positive regulation of transcription, DNA-templated; endoplasmic reticulum unfolded protein response; positive regulation of gene expression; positive regulation of reactive oxygen species metabolic process; positive regulation of blood coagulation; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; protein ubiquitination; cellular response to oxidative stress; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of hydrogen peroxide-induced cell death; inflammatory response; regulation of removal of superoxide radicals; positive regulation of transcription by RNA polymerase II; cellular response to hydrogen peroxide; proteasome-mediated ubiquitin-dependent protein catabolic process; positive regulation of blood vessel endothelial cell migration; human ageing; cellular response to hypoxia; negative regulation of vascular associated smooth muscle cell migration; negative regulation of cardiac muscle cell apoptotic process; transcription by RNA polymerase II; positive regulation of angiogenesis; positive regulation of neuron projection development; aflatoxin catabolic process; cellular response to angiotensin; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; viral process;
	Sources:Amigo / QuickGO
Orthologs
	4780
	18024
	ENSG00000116044
	ENSMUSG00000015839
	Q16236
	Q60795
NM_006164; NM_001145412; NM_001145413; NM_001313900; NM_001313901;
	NM_001313902; NM_001313903; NM_001313904
	NM_010902; NM_001399226
NP_001138884; NP_001138885; NP_001300829; NP_001300830; NP_001300831;
	NP_001300832; NP_001300833; NP_006155
	NP_035032; NP_001386155
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that may regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation, according to preliminary research. In vitro, NRF2 binds to antioxidant response elements (AREs) in the promoter regions of genes encoding cytoprotective proteins. NRF2 induces the expression of heme oxygenase 1 in vitro leading to an increase in phase II enzymes. NRF2 also inhibits the NLRP3 inflammasome.

NRF2 appears to participate in a complex regulatory network and performs a pleiotropic role in the regulation of metabolism, inflammation, autophagy, proteostasis, mitochondrial physiology, and immune responses. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.

A mechanism for hormetic dose responses is proposed in which Nrf2 may serve as an hormetic mediator that mediates a vast spectrum of chemopreventive processes.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.