Myogenin

MYOG
Identifiers
Aliases	MYOG, MYF4, bHLHc3, myf-4, myogenin (myogenic factor 4), myogenin
External IDs	OMIM: 159980 MGI: 97276 HomoloGene: 1854 GeneCards: MYOG
Gene location (Human)
Chr.	Chromosome 1 (human)
End	203,086,012 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	134,220,286 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; triceps brachii muscle; ; vastus lateralis muscle; ; tibialis anterior muscle; ; jejunum; ; mouth; ; rhombencephalon; ; hippocampal formation; ; temporal lobe; ; metencephalon;
	Top expressed in
	superior surface of tongue; ; internal carotid artery; ; pineal gland; ; plantaris muscle; ; dermis; ; ankle joint; ; extraocular muscle; ; extensor digitorum longus muscle; ; thoracic diaphragm; ; urethra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; E-box binding; protein binding; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; chromatin DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; protein-DNA complex; nucleus; nucleoplasm;
Biological process	cellular response to retinoic acid; positive regulation of myotube differentiation; cell differentiation; myotube differentiation; negative regulation of glycolytic process; regulation of transcription, DNA-templated; cellular response to lithium ion; ossification; positive regulation of muscle cell differentiation; response to muscle activity involved in regulation of muscle adaptation; muscle cell fate commitment; cellular response to growth factor stimulus; cellular response to estradiol stimulus; positive regulation of oxidative phosphorylation; muscle organ development; striated muscle atrophy; mRNA transcription by RNA polymerase II; cellular response to magnetism; positive regulation of skeletal muscle fiber development; transcription, DNA-templated; multicellular organism development; positive regulation of transcription, DNA-templated; response to gravity; positive regulation of myoblast fusion; positive regulation of muscle atrophy; skeletal muscle tissue regeneration; positive regulation of myoblast differentiation; skeletal muscle fiber development; response to electrical stimulus involved in regulation of muscle adaptation; skeletal muscle atrophy; skeletal muscle cell differentiation; response to denervation involved in regulation of muscle adaptation; cell cycle; regulation of myoblast fusion; myoblast differentiation; regulation of skeletal muscle satellite cell proliferation; skeletal muscle tissue development; response to muscle activity; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; cellular response to tumor necrosis factor;
	Sources:Amigo / QuickGO
Orthologs
	4656
	17928
	ENSG00000122180
	ENSMUSG00000026459
	P15173
	P12979
	NM_002479
	NM_031189
	NP_002470
	NP_112466
	Wikidata
View/Edit Human	View/Edit Mouse

Myogenin, is a transcriptional activator encoded by the MYOG gene. Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and MRF4.

In mice, myogenin is essential for the development of functional skeletal muscle. Myogenin is required for the proper differentiation of most myogenic precursor cells during the process of myogenesis. When the DNA coding for myogenin was knocked out of the mouse genome, severe skeletal muscle defects were observed. Mice lacking both copies of myogenin (homozygous-null) suffer from perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body.

In cell culture, myogenin can induce myogenesis in a variety of non-muscle cell types.

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