Merlin (protein)

NF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZRJ, 1H4R, 3U8Z, 4ZRI
Identifiers
Aliases	NF2, ACN, BANF, SCH, neurofibromin 2 (merlin), neurofibromin 2, merlin-1, moesin-ezrin-radixin like (MERLIN) tumor suppressor
External IDs	OMIM: 607379 MGI: 97307 HomoloGene: 2180 GeneCards: NF2
Gene location (Human)
Chr.	Chromosome 22 (human)
End	29,698,598 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	4,799,536 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; Region I of hippocampus proper; ; postcentral gyrus; ; vastus lateralis muscle; ; triceps brachii muscle; ; entorhinal cortex; ; inferior olivary nucleus; ; Achilles tendon; ; Brodmann area 46; ; skeletal muscle tissue;
	Top expressed in
	saccule; ; otic placode; ; submandibular gland; ; secondary oocyte; ; molar; ; myocardium of ventricle; ; extensor digitorum longus muscle; ; plantaris muscle; ; lip; ; spermatocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cytoskeletal protein binding; protein binding; actin binding;
Cellular component	cytoplasm; cell body; cell projection; membrane; filopodium; ruffle; adherens junction; plasma membrane; apical part of cell; ruffle membrane; early endosome; nucleolus; cortical actin cytoskeleton; perinuclear region of cytoplasm; neuron projection; cleavage furrow; cytoskeleton; nucleus; lamellipodium; filopodium membrane; cytosol;
Biological process	negative regulation of receptor signaling pathway via JAK-STAT; regulation of gliogenesis; cell-cell junction organization; regulation of protein stability; negative regulation of cell-cell adhesion; negative regulation of protein kinase activity; mesoderm formation; ectoderm development; negative regulation of DNA replication; Schwann cell proliferation; regulation of neural precursor cell proliferation; regulation of protein localization to nucleus; negative regulation of cell-matrix adhesion; odontogenesis of dentin-containing tooth; brain development; negative regulation of cell migration; lens fiber cell differentiation; regulation of cell population proliferation; positive regulation of cell differentiation; negative regulation of MAPK cascade; regulation of hippo signaling; hippocampus development; regulation of stem cell proliferation; regulation of neurogenesis; actin cytoskeleton organization; positive regulation of stress fiber assembly; negative regulation of cell population proliferation; negative regulation of tyrosine phosphorylation of STAT protein; regulation of apoptotic process; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	4771
	18016
	ENSG00000186575
	ENSMUSG00000009073
	P35240
	P46662
NM_181835; NM_000268; NM_016418; NM_181825; NM_181826;
	NM_181827; NM_181828; NM_181829; NM_181830; NM_181831; NM_181832; NM_181833; NM_181834
NM_001252250; NM_001252251; NM_001252252; NM_001252253; NM_010898;
	NM_001361675; NM_001361676; NM_001361677
NP_000259; NP_057502; NP_861546; NP_861966; NP_861967;
	NP_861968; NP_861969; NP_861970; NP_861971
NP_001239179; NP_001239180; NP_001239181; NP_001239182; NP_035028;
	NP_001348604; NP_001348605; NP_001348606
	Wikidata
View/Edit Human	View/Edit Mouse

Merlin (also called neurofibromin 2 or schwannomin) is a cytoskeletal protein. In humans, it is a tumor suppressor protein involved in neurofibromatosis type II. Sequence data reveal its similarity to the ERM protein family.

The name "merlin" is an acronym for "Moesin-Ezrin-Radixin-Like Protein".

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