Radixin

RDX
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GC6, 1GC7, 1J19, 2D10, 2D11, 2D2Q, 2EMS, 2EMT, 2YVC, 2ZPY
Identifiers
Aliases	RDX, DFNB24, radixin
External IDs	OMIM: 179410 MGI: 97887 HomoloGene: 37707 GeneCards: RDX
Gene location (Human)
Chr.	Chromosome 11 (human)
End	110,296,712 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	52,011,763 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; parietal pleura; ; left adrenal gland; ; corpus callosum; ; secondary oocyte; ; tibia; ; Achilles tendon; ; biceps brachii; ; ganglionic eminence; ; metanephric glomerulus;
	Top expressed in
	secondary oocyte; ; cumulus cell; ; dermis; ; atrium; ; lacrimal gland; ; abdominal wall; ; pineal gland; ; seminal vesicula; ; left lung lobe; ; otic placode;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein domain specific binding; ATPase binding; protein kinase A binding; cytoskeletal protein binding; protein binding; actin binding; RNA binding; cadherin binding;
Cellular component	cytoplasm; membrane; focal adhesion; filopodium; ruffle; myelin sheath; plasma membrane; apical part of cell; stereocilium; microvillus; apical plasma membrane; cortical actin cytoskeleton; cleavage furrow; extracellular exosome; cytoskeleton; cell periphery; lamellipodium; midbody; T-tubule; cell tip; extracellular space; cell projection;
Biological process	regulation of cell size; establishment of endothelial barrier; microvillus assembly; regulation of organelle assembly; establishment of protein localization; positive regulation of cell migration; regulation of GTPase activity; positive regulation of G1/S transition of mitotic cell cycle; negative regulation of homotypic cell-cell adhesion; regulation of actin filament bundle assembly; positive regulation of gene expression; negative regulation of GTPase activity; negative regulation of adherens junction organization; apical protein localization; actin filament capping; cellular response to thyroid hormone stimulus; regulation of cell shape; protein kinase A signaling; regulation of ruffle assembly; positive regulation of protein localization to early endosome; positive regulation of early endosome to late endosome transport; negative regulation of cell size; regulation of Rap protein signal transduction; cellular response to platelet-derived growth factor stimulus; barbed-end actin filament capping; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	5962
	19684
	ENSG00000137710
	ENSMUSG00000032050
	P35241
	P26043
NM_002906; NM_001260492; NM_001260493; NM_001260494; NM_001260495;
	NM_001260496
	NM_001104616; NM_001104617; NM_009041
NP_001247421; NP_001247422; NP_001247423; NP_001247424; NP_001247425;
	NP_002897
	NP_001098086; NP_001098087; NP_033067
	Wikidata
View/Edit Human	View/Edit Mouse

Radixin is a protein that in humans is encoded by the RDX gene.

Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses.

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