Medial longitudinal fasciculus
The medial longitudinal fasciculus (MLF) is an area of crossed over tracts, on each side of the brainstem. These bundles of axons are situated near the midline of the brainstem. They are made up of both ascending and descending fibers that arise from a number of sources and terminate in different areas, including the superior colliculus, the vestibular nuclei, and the cerebellum. It contains the interstitial nucleus of Cajal, responsible for oculomotor control, head posture, and vertical eye movement.
| Medial longitudinal fasciculus | |
|---|---|
Transverse section of mid-brain at level of inferior colliculi. (Medial longitudinal fasciculus labeled at center right.) | |
Axial section through mid-brain. 1. Corpora quadrigemina. 2. Cerebral aqueduct. 3. Central gray stratum. 4. Interpeduncular space. 5. Sulcus lateralis. 6. Substantia nigra. 7. Red nucleus of tegmentum. 8. Oculomotor nerve, with 8’, its nucleus oforigin. a. Lemniscus (in blue) with a’ the medial lemniscus and a" the lateral lemniscus. b. Medial longitudinal fasciculus. c. Raphe. d. Temporopontine fibers. e. Portion of medial lemniscus, which runs to the lentiform nucleus and insula. f. Cerebrospinal fibers. g. Frontopontine fibers. | |
| Details | |
| Identifiers | |
| Latin | fasciculus longitudinalis medialis |
| NeuroNames | 1588, 784 |
| NeuroLex ID | nlx_144065 |
| TA98 | A14.1.04.113 A14.1.05.304 A14.1.06.209 |
| TA2 | 5867 |
| FMA | 83846 |
| Anatomical terms of neuroanatomy | |
The medial longitudinal fasciculus is the main central connection for the oculomotor nerve, trochlear nerve, and abducens nerve. It carries information about the direction that the eyes should move. Lesions of the medial longitudinal fasciculus can cause nystagmus and diplopia, which may be associated with multiple sclerosis, a neoplasm, or a stroke.