Matrix Gla protein

MGP
Identifiers
Aliases	MGP, MGLAP, NTI, GIG36, matrix Gla protein
External IDs	OMIM: 154870 MGI: 96976 HomoloGene: 693 GeneCards: MGP
Gene location (Human)
Chr.	Chromosome 12 (human)
End	14,885,857 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	136,852,821 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; right coronary artery; ; left coronary artery; ; left uterine tube; ; lactiferous duct; ; pericardium; ; saphenous vein; ; Achilles tendon; ; synovial joint; ; vena cava;
	Top expressed in
	right lung lobe; ; aortic valve; ; carotid body; ; left lung; ; calvaria; ; ascending aorta; ; left lung lobe; ; superior surface of tongue; ; intercostal muscle; ; belly cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; extracellular matrix structural constituent; protein binding; structural constituent of bone;
Cellular component	extracellular matrix; extracellular region; extracellular exosome; collagen-containing extracellular matrix;
Biological process	multicellular organism development; cell differentiation; cartilage development; cartilage condensation; ossification; regulation of bone mineralization;
	Sources:Amigo / QuickGO
Orthologs
	4256
	17313
	ENSG00000111341
	ENSMUSG00000030218
	P08493
	P19788
	NM_001190839; NM_000900
	NM_008597
	NP_000891; NP_001177768
	NP_032623
	Wikidata
View/Edit Human	View/Edit Mouse

Matrix Gla protein (MGP) is member of a family of vitamin K₂ dependent, Gla-containing proteins. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization.

MGP is found in a number of body tissues in mammals, birds, and fish. Its mRNA is present in bone, cartilage, heart, and kidney.

It is present in bone together with the related vitamin K2-dependent protein osteocalcin. In bone, its production is increased by vitamin D.

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