MYC

MYC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A93, 1EE4, 1MV0, 1NKP, 2A93, 2OR9, 4Y7R
Identifiers
Aliases	MYC, MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc, c-myc
External IDs	OMIM: 190080 MGI: 97250 HomoloGene: 31092 GeneCards: MYC
Gene location (Human)
Chr.	Chromosome 8 (human)
End	127,742,951 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	61,862,223 bp
RNA expression pattern
	Top expressed in
	vena cava; ; left uterine tube; ; skin of abdomen; ; gastric mucosa; ; human penis; ; mucosa of urinary bladder; ; pericardium; ; gallbladder; ; lactiferous duct; ; nipple;
	Top expressed in
	lip; ; yolk sac; ; thymus; ; morula; ; nasal septum; ; uterus; ; esophagus; ; cervix; ; parotid gland; ; calvaria;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; E-box binding; protein binding; protein-containing complex binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleolus; nucleus; protein-containing complex;
Biological process	Notch signaling pathway; chromatin remodeling; negative regulation of monocyte differentiation; positive regulation of metanephric cap mesenchymal cell proliferation; regulation of transcription, DNA-templated; regulation of telomere maintenance; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; cellular response to UV; oxygen transport; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; chromosome organization; MAPK cascade; cellular response to DNA damage stimulus; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; branching involved in ureteric bud morphogenesis; negative regulation of cell division; fibroblast apoptotic process; positive regulation of mesenchymal cell proliferation; positive regulation of response to DNA damage stimulus; positive regulation of cell population proliferation; positive regulation of DNA biosynthetic process; regulation of gene expression; canonical Wnt signaling pathway; negative regulation of stress-activated MAPK cascade; energy reserve metabolic process; response to growth factor; response to gamma radiation; negative regulation of fibroblast proliferation; positive regulation of transcription by RNA polymerase II; cellular iron ion homeostasis; beta-catenin-TCF complex assembly; transcription, DNA-templated; transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; protein deubiquitination; positive regulation of transcription, DNA-templated; positive regulation of telomerase activity; positive regulation of gene expression; protein-DNA complex disassembly; ERK1 and ERK2 cascade; cellular response to hypoxia; G1/S transition of mitotic cell cycle; cytokine-mediated signaling pathway; positive regulation of DNA methylation;
	Sources:Amigo / QuickGO
Orthologs
	4609
	17869
	ENSG00000136997
	ENSMUSG00000022346
	P01106
	P01108
	NM_002467; NM_001354870
	NM_001177352; NM_001177353; NM_001177354; NM_010849
	NP_002458; NP_001341799
	NP_001170823; NP_001170824; NP_001170825; NP_034979
	Wikidata
View/Edit Human	View/Edit Mouse

MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the myc family of transcription factors. The protein contains basic helix-loop-helix (bHLH) structural motif.

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