Basic helix–loop–helix

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1a0a, 1am9, 1an2, 1an4, 1hlo, 1mdy, 1nkp, 1nlw, 1r05, 1ukl, 2ql2

Basic helix–loop–helix DNA-binding domain
Basic helix–loop–helix DNA-binding domain
	Basic helix–loop–helix structural motif of ARNT. Two α-helices (blue) are connected by a short loop (red).
Identifiers
Symbol	bHLH
Pfam	PF00010
InterPro	IPR001092
SMART	SM00353
PROSITE	PDOC00038
SCOP2	1mdy / SCOPe / SUPFAM
CDD	cd00083
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1a0a, 1am9, 1an2, 1an4, 1hlo, 1mdy, 1nkp, 1nlw, 1r05, 1ukl, 2ql2

A basic helix–loop–helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors. The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general contain basic amino acid residues in order to facilitate DNA binding.

bHLH transcription factors are often important in development or cell activity. For one, BMAL1-Clock (also called ARNTL) is a core transcription complex in the molecular circadian clock. Other genes, like c-Myc and HIF-1, have been linked to cancer due to their effects on cell growth and metabolism.

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