Macrophage colony-stimulating factor

CSF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HMC, 3UEZ, 3UF2, 4ADF, 4FA8, 4WRL, 4WRM
Identifiers
Aliases	CSF1, CSF-1, MCSF, colony stimulating factor 1
External IDs	OMIM: 120420 MGI: 1339753 HomoloGene: 7282 GeneCards: CSF1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	109,930,992 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	107,667,785 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; subcutaneous adipose tissue; ; right coronary artery; ; left adrenal gland; ; left coronary artery; ; right adrenal gland; ; left uterine tube; ; upper lobe of left lung; ; spleen; ; tibial nerve;
	Top expressed in
	aortic valve; ; ascending aorta; ; calvaria; ; ankle joint; ; secondary oocyte; ; supraoptic nucleus; ; median eminence; ; femur; ; body of femur; ; spleen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; macrophage colony-stimulating factor receptor binding; protein homodimerization activity; growth factor activity; cytokine activity; identical protein binding;
Cellular component	integral component of membrane; perinuclear region of cytoplasm; CSF1-CSF1R complex; membrane; extracellular space; endoplasmic reticulum lumen; extracellular region; plasma membrane;
Biological process	positive regulation of microglial cell migration; cell differentiation; positive regulation of protein metabolic process; mammary gland fat development; branching involved in mammary gland duct morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; immune system process; positive regulation of Ras protein signal transduction; positive regulation of macrophage colony-stimulating factor signaling pathway; mammary duct terminal end bud growth; monocyte activation; positive regulation of macrophage derived foam cell differentiation; positive regulation of gene expression; macrophage colony-stimulating factor signaling pathway; positive regulation of odontogenesis of dentin-containing tooth; positive regulation of cell population proliferation; regulation of macrophage derived foam cell differentiation; positive regulation of multicellular organism growth; homeostasis of number of cells within a tissue; regulation of ossification; inflammatory response; positive regulation of macrophage chemotaxis; innate immune response; positive regulation of mononuclear cell proliferation; osteoclast proliferation; positive regulation of osteoclast differentiation; positive regulation of cell migration; positive regulation of monocyte differentiation; positive regulation of protein kinase activity; developmental process involved in reproduction; positive regulation of cell-matrix adhesion; positive regulation of macrophage differentiation; cell population proliferation; macrophage differentiation; post-translational protein modification; regulation of signaling receptor activity; cytokine-mediated signaling pathway; hemopoiesis; osteoclast differentiation; response to ischemia; microglial cell proliferation; negative regulation of neuron death;
	Sources:Amigo / QuickGO
Orthologs
	1435
	12977
	ENSG00000184371
	ENSMUSG00000014599
	P09603
	P07141
	NM_172212; NM_000757; NM_172210; NM_172211
	NM_001113529; NM_001113530; NM_007778
	NP_000748; NP_757349; NP_757350; NP_757351
	NP_001107001; NP_001107002; NP_031804
	Wikidata
View/Edit Human	View/Edit Mouse

The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which causes hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 receptor. It may also be involved in development of the placenta.

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