Colony stimulating factor 1 receptor

CSF1R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM
Identifiers
Aliases	CSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, colony stimulating factor 1 receptor, BANDDOS, HDLS1
External IDs	OMIM: 164770 MGI: 1339758 HomoloGene: 3817 GeneCards: CSF1R
EC number	2.7.10.1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,113,372 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	61,265,221 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spleen; ; right coronary artery; ; placenta; ; inferior ganglion of vagus nerve; ; retinal pigment epithelium; ; gallbladder; ; appendix; ; lymph node; ; synovial joint;
	Top expressed in
	retinal pigment epithelium; ; ankle; ; motor neuron; ; internal carotid artery; ; calvaria; ; substantia nigra; ; globus pallidus; ; spleen; ; external carotid artery; ; body of femur;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein tyrosine kinase activity; protein kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; kinase activity; protein homodimerization activity; ATP binding; protein phosphatase binding; macrophage colony-stimulating factor receptor activity; cytokine binding; protein binding; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; cell surface; CSF1-CSF1R complex; nucleoplasm; plasma membrane; intracellular membrane-bounded organelle; cytoplasm; receptor complex;
Biological process	negative regulation of cell population proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of protein serine/threonine kinase activity; mammary gland duct morphogenesis; positive regulation of cell motility; macrophage colony-stimulating factor signaling pathway; phosphatidylinositol-mediated signaling; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; signal transduction; axon guidance; multicellular organism development; monocyte differentiation; macrophage differentiation; ruffle organization; positive regulation of cell migration; cellular response to cytokine stimulus; protein autophosphorylation; peptidyl-tyrosine phosphorylation; olfactory bulb development; regulation of bone resorption; phosphatidylinositol metabolic process; protein phosphorylation; positive regulation of protein tyrosine kinase activity; cell-cell junction maintenance; osteoclast differentiation; innate immune response; regulation of actin cytoskeleton reorganization; immune system process; inflammatory response; positive regulation of protein phosphorylation; forebrain neuron differentiation; phosphorylation; cellular response to macrophage colony-stimulating factor stimulus; positive regulation of cell population proliferation; regulation of cell shape; cell population proliferation; positive regulation of tyrosine phosphorylation of STAT protein; cytokine-mediated signaling pathway; hemopoiesis; negative regulation of signal transduction; cell differentiation; hematopoietic progenitor cell differentiation; positive regulation of MAPK cascade; response to ischemia; microglial cell proliferation; positive regulation by host of viral process;
	Sources:Amigo / QuickGO
Orthologs
	1436
	12978
	ENSG00000182578
	ENSMUSG00000024621
	P07333
	P09581
	NM_001288705; NM_005211; NM_001349736; NM_001375320; NM_001375321
	NM_001037859; NM_007779
	NP_001275634; NP_005202; NP_001336665; NP_001362249; NP_001362250
	NP_001032948
	Wikidata
View/Edit Human	View/Edit Mouse

Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded by the human CSF1R gene (known also as c-FMS). CSF1R is a receptor that can be activated by two ligands: colony stimulating factor 1 (CSF-1) and interleukin-34 (IL-34). CSF1R is highly expressed in myeloid cells, and CSF1R signaling is necessary for the survival, proliferation, and differentiation of many myeloid cell types in vivo and in vitro. CSF1R signaling is involved in many diseases and is targeted in therapies for cancer, neurodegeneration, and inflammatory bone diseases.

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