Loratadine

Loratadine
Clinical data
Trade names	Claritin, Claratyne, Clarityn, others
AHFS/Drugs.com	Monograph
MedlinePlus	a697038
License data	US DailyMed: Loratadine;
Pregnancy; category	AU: B1;
Routes of; administration	By mouth
Drug class	Second-generation antihistamine
ATC code	R06AX13 (WHO) ;
Legal status
Legal status	AU: OTC; CA: OTC; UK: General sales list (GSL, OTC) / Pharmacy; US: WARNINGOTC / Rx-only;
Pharmacokinetic data
Bioavailability	almost 100%
Protein binding	97–99%
Metabolism	Liver (CYP2D6- and 3A4-mediated)
Elimination half-life	8 hours, active metabolite desloratadine 27 hours
Excretion	40% as conjugated metabolites into urine; Similar amount into the feces
Identifiers
	IUPAC name Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate;
CAS Number	79794-75-5 ;
PubChem CID	3957;
IUPHAR/BPS	7216;
DrugBank	DB00455 ;
ChemSpider	3820 ;
UNII	7AJO3BO7QN;
KEGG	D00364 ;
ChEBI	CHEBI:6538 ;
ChEMBL	ChEMBL998 ;
CompTox Dashboard (EPA)	DTXSID2023224 ;
ECHA InfoCard	100.120.122
Chemical and physical data
Formula	C22H23ClN2O2
Molar mass	382.89 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)N4CC/C(=C2/c1ccc(Cl)cc1CCc3cccnc23)CC4;
	InChI InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3 ; Key:JCCNYMKQOSZNPW-UHFFFAOYSA-N ;
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Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. This includes allergic rhinitis (hay fever) and hives. It is also available in drug combinations such as loratadine/pseudoephedrine, in which it is combined with pseudoephedrine, a nasal decongestant. It is taken orally.

Common side effects include sleepiness, dry mouth, and headache. Serious side effects are rare and include allergic reactions, seizures, and liver problems. Use during pregnancy appears to be safe but has not been well studied. It is not recommended in children less than two years old. It is in the second-generation antihistamine family of medication.

Loratadine was patented in 1980 and came to market in 1988. It is on the World Health Organization's List of Essential Medicines. Loratadine is available as a generic medication. In the United States, it is available over the counter. In 2021, it was the 67th most commonly prescribed medication in the United States, with more than 9 million prescriptions.

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