Desloratadine

Desloratadine
Clinical data
Trade names	Clarinex, Aerius, Allex, others
AHFS/Drugs.com	Monograph
MedlinePlus	a602002
License data	EU EMA: by INN; US DailyMed: Desloratadine; US FDA: Desloratadine;
Pregnancy; category	AU: B1;
Routes of; administration	By mouth (tablets, solution)
ATC code	R06AX27 (WHO) ;
Legal status
Legal status	AU: S2 (Pharmacy medicine); CA: OTC; UK: POM (Prescription only); US: ℞-only; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	Rapidly absorbed
Protein binding	83 to 87%
Metabolism	UGT2B10, CYP2C8
Metabolites	3-Hydroxydesloratadine
Onset of action	within 1 hour
Elimination half-life	27 hours
Duration of action	up to 24 hours
Excretion	40% as conjugated metabolites into urine; Similar amount into the feces
Identifiers
	IUPAC name 8-chloro-6,11-dihydro-11-(4-piperdinylidene)- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine;
CAS Number	100643-71-8 ;
PubChem CID	124087;
IUPHAR/BPS	7157;
DrugBank	DB00967 ;
ChemSpider	110575 ;
UNII	FVF865388R;
KEGG	D03693 ;
ChEBI	CHEBI:291342 ;
ChEMBL	ChEMBL1172 ;
CompTox Dashboard (EPA)	DTXSID1044196 ;
ECHA InfoCard	100.166.554
Chemical and physical data
Formula	C19H19ClN2
Molar mass	310.83 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc4cc2c(C(/c1ncccc1CC2)=C3/CCNCC3)cc4;
	InChI InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 ; Key:JAUOIFJMECXRGI-UHFFFAOYSA-N ;
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Desloratadine (trade names Clarinex and Aerius) is a tricyclic H₁ inverse agonist that is used to treat allergies. It is an active metabolite of loratadine.

It was patented in 1984 and came into medical use in 2001.

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