CD98

CD98 is a glycoprotein that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids. LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.

solute carrier family 3 member 2 (activators of dibasic and neutral amino acid transport)
Identifiers
SymbolSLC3A2
Alt. symbolsMDU1, 4T2HC, 4F2, NACAE, CD98
NCBI gene6520
HGNC11026
OMIM158070
RefSeqNM_001013251
UniProtP08195
Other data
LocusChr. 11 q12-q22
Search for
StructuresSwiss-model
DomainsInterPro
solute carrier family 7 member 5 (cationic amino acid transporter, y+ system)
Identifiers
SymbolSLC7A5
Alt. symbolsLAT1, E16, D16S469E, MPE16, CD98
NCBI gene8140
HGNC11063
OMIM600182
RefSeqNM_003486
UniProtQ01650
Other data
LocusChr. 16 q24.3
Search for
StructuresSwiss-model
DomainsInterPro

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

  • 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene
  • CD98 light subunit protein encoded by the SLC7A5 gene
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