KLF4

KLF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WBS, 2WBU, 4M9E
Identifiers
Aliases	KLF4, EZF, GKLF, Kruppel-like factor 4 (gut), Kruppel like factor 4
External IDs	OMIM: 602253 MGI: 1342287 HomoloGene: 3123 GeneCards: KLF4
Gene location (Human)
Chr.	Chromosome 9 (human)
End	107,490,482 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	55,532,466 bp
RNA expression pattern
	Top expressed in
	human penis; ; synovial joint; ; skin of abdomen; ; vulva; ; jejunal mucosa; ; nipple; ; gastric mucosa; ; urethra; ; gums; ; cavity of mouth;
	Top expressed in
	epithelium of stomach; ; mucous cell of stomach; ; conjunctival fornix; ; left colon; ; pyloric antrum; ; intestinal villus; ; belly cord; ; cervix; ; stria vascularis; ; skin of abdomen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; beta-catenin binding; phosphatidylinositol 3-kinase regulator activity; DNA-binding transcription factor activity; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; cis-regulatory region sequence-specific DNA binding; metal ion binding; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; protein binding; nucleic acid binding; double-stranded DNA binding; promoter-specific chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription coregulator binding; histone deacetylase binding;
Cellular component	cytoplasm; transcription regulator complex; nucleoplasm; chromatin; nucleus;
Biological process	negative regulation of chemokine (C-X-C motif) ligand 2 production; epidermal cell differentiation; cellular response to retinoic acid; negative regulation of protein kinase B signaling; negative regulation of muscle hyperplasia; negative regulation of smooth muscle cell proliferation; positive regulation of protein metabolic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of axon regeneration; cellular response to peptide; regulation of transcription, DNA-templated; positive regulation of hemoglobin biosynthetic process; response to retinoic acid; somatic stem cell population maintenance; cellular response to laminar fluid shear stress; regulation of transcription by RNA polymerase II; cell differentiation; epidermis morphogenesis; positive regulation of nitric oxide biosynthetic process; cellular response to growth factor stimulus; cellular response to organic cyclic compound; post-embryonic hemopoiesis; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; response to organic substance; negative regulation of gene expression; negative regulation of response to cytokine stimulus; transcription, DNA-templated; negative regulation of DNA-binding transcription factor activity; negative regulation of phosphatidylinositol 3-kinase signaling; stem cell population maintenance; negative regulation of cell migration involved in sprouting angiogenesis; positive regulation of gene expression; negative regulation of cell migration; regulation of cell population proliferation; post-embryonic camera-type eye development; regulation of phosphatidylinositol 3-kinase activity; positive regulation of telomerase activity; canonical Wnt signaling pathway; negative regulation of ERK1 and ERK2 cascade; regulation of cell differentiation; mesodermal cell fate determination; negative regulation of heterotypic cell-cell adhesion; negative regulation of transcription, DNA-templated; negative regulation of NF-kappaB transcription factor activity; cellular response to cycloheximide; negative regulation of inflammatory response; fat cell differentiation; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; cellular response to hydrogen peroxide; negative regulation of leukocyte adhesion to arterial endothelial cell; positive regulation of core promoter binding; cellular response to leukemia inhibitory factor; negative regulation of angiogenesis; pri-miRNA transcription by RNA polymerase II; negative regulation of G1/S transition of mitotic cell cycle; positive regulation of transcription, DNA-templated; positive regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	9314
	16600
	ENSG00000136826
	ENSMUSG00000003032
	O43474
	Q60793
	NM_001314052; NM_004235
	NM_010637
	NP_001300981; NP_004226
	NP_034767
	Wikidata
View/Edit Human	View/Edit Mouse

Kruppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of SP1-like transcription factors. KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including colorectal cancer. It has three C2H2-zinc fingers at its carboxyl terminus that are closely related to another KLF, KLF2. It has two nuclear localization sequences that signals it to localize to the nucleus. In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSCs).

In humans, the protein is 513 amino acids, with a predicted molecular weight of approximately 55kDa, and is encoded by the KLF4 gene. The KLF4 gene is conserved in chimpanzee, rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. KLF4 was first identified in 1996.

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