KLF2

KLF2
Identifiers
Aliases	KLF2, LKLF, Kruppel-like factor 2, Kruppel like factor 2
External IDs	OMIM: 602016 MGI: 1342772 HomoloGene: 133978 GeneCards: KLF2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	16,328,685 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	73,075,500 bp
RNA expression pattern
	Top expressed in
	urethra; ; vena cava; ; trachea; ; saphenous vein; ; gastric mucosa; ; nipple; ; pericardium; ; cardia; ; pylorus; ; trigeminal ganglion;
	Top expressed in
	right lung; ; ankle joint; ; right lung lobe; ; spleen; ; subcutaneous adipose tissue; ; ankle; ; endocardial cushion; ; left lung; ; blood; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA-binding transcription factor activity; metal ion binding; protein binding; nucleic acid binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	cellular response to peptide; regulation of transcription, DNA-templated; regulation of gene expression, epigenetic; multicellular organism growth; cellular response to laminar fluid shear stress; positive regulation of transcription from RNA polymerase II promoter in response to stress; positive regulation of nitric oxide biosynthetic process; negative regulation of interleukin-6 production; cellular response to tumor necrosis factor; cellular response to organic cyclic compound; response to laminar fluid shear stress; in utero embryonic development; transcription, DNA-templated; positive regulation of transcription, DNA-templated; erythrocyte homeostasis; type I pneumocyte differentiation; cellular response to interleukin-1; cell morphogenesis; cellular response to cycloheximide; cellular response to hydrogen peroxide; erythrocyte maturation; positive regulation of transcription by RNA polymerase II; cellular response to fluid shear stress; negative regulation of transcription by RNA polymerase II; cellular stress response to acid chemical; negative regulation of sprouting angiogenesis; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	10365
	16598
	ENSG00000127528
	ENSMUSG00000055148
	Q9Y5W3
	Q60843
	NM_016270; NM_006075; NM_016198
	NM_008452
	NP_057354
	NP_032478
	Wikidata
View/Edit Human	View/Edit Mouse

Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.

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