Interleukin 11

IL11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MHL
Identifiers
Aliases	IL11, AGIF, IL-11, interleukin 11
External IDs	OMIM: 147681 MGI: 107613 HomoloGene: 535 GeneCards: IL11
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,370,463 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,785,858 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; stromal cell of endometrium; ; mucosa of urinary bladder; ; cecum; ; hypothalamus; ; anterior pituitary; ; appendix; ; gallbladder; ; skin of abdomen; ; occipital lobe;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; muscle; ; lip; ; cerebellum; ; amygdala; ; cerebellar cortex; ; face; ; adipose tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	growth factor activity; interleukin-11 receptor binding; cytokine activity; protein binding;
Cellular component	cytoplasm; extracellular space; extracellular region;
Biological process	negative regulation of endothelial cell apoptotic process; positive regulation of MAPK cascade; positive regulation of peptidyl-serine phosphorylation; B cell differentiation; positive regulation of transcription by RNA polymerase II; negative regulation of hormone secretion; positive regulation of peptidyl-tyrosine phosphorylation; fat cell differentiation; positive regulation of cell population proliferation; regulation of complement-dependent cytotoxicity; megakaryocyte differentiation; regulation of signaling receptor activity; cytokine-mediated signaling pathway; cardiovascular fibrosis;
	Sources:Amigo / QuickGO
Orthologs
	3589
	16156
	ENSG00000095752
	ENSMUSG00000004371
	P20809
	P47873
	NM_001267718; NM_000641
	NM_008350; NM_001290423
	NP_000632; NP_001254647
	NP_001277352; NP_032376
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that in humans is encoded by the IL11 gene.

IL-11 is a cytokine that was first isolated in 1990 from bone marrow-derived fibrocyte-like stromal cells. It was initially thought to be important for hematopoiesis, notably for megakaryocyte maturation, but subsequently shown to be redundant for platelets, and for other blood cell types, in both mice and humans. It was developed as a recombinant protein (rhIL-11) as the drug substance oprelvekin.

The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, and encodes a 23 kDa protein. IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130. Signal specificity is provided by the IL-11Rα subunit which is expressed at high levels in fibroblasts and other stromal cells but not immune cells, unlike IL6 receptors that are expressed at highest levels in immune cells and lowly expressed in stromal cells.

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