Interleukin 1 beta

IL1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HIB, 1I1B, 1IOB, 1ITB, 1L2H, 1S0L, 1T4Q, 1TOO, 1TP0, 1TWE, 1TWM, 21BI, 2I1B, 2KH2, 2NVH, 31BI, 3O4O, 3POK, 41BI, 4DEP, 4G6J, 4G6M, 4GAI, 4I1B, 5I1B, 6I1B, 7I1B, 9ILB, 4GAF, 5BVP
Identifiers
Aliases	IL1B, IL-1, IL1-BETA, IL1F2, interleukin 1 beta, IL1beta
External IDs	OMIM: 147720 MGI: 96543 HomoloGene: 481 GeneCards: IL1B
Gene location (Human)
Chr.	Chromosome 2 (human)
End	112,836,816 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	129,213,059 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; monocyte; ; blood; ; bone marrow cells; ; pancreatic ductal cell; ; gallbladder; ; appendix; ; spleen; ; mucosa of urinary bladder; ; stromal cell of endometrium;
	Top expressed in
	blood; ; spleen; ; bone marrow; ; islet of Langerhans; ; right lung; ; right ventricle; ; cervix; ; right lung lobe; ; left lobe of liver; ; jejunum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; interleukin-1 receptor binding; cytokine activity; integrin binding; protein binding;
Cellular component	cytoplasm; cytosol; extracellular region; lysosome; extracellular exosome; secretory granule; vesicle; extracellular space;
Biological process	positive regulation of protein phosphorylation; smooth muscle adaptation; positive regulation of calcidiol 1-monooxygenase activity; negative regulation of insulin receptor signaling pathway; cellular response to mechanical stimulus; positive regulation of interleukin-8 production; positive regulation of mitotic nuclear division; response to carbohydrate; embryo implantation; regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of cell population proliferation; apoptotic process; cellular response to organic substance; positive regulation of phagocytosis; regulation of insulin secretion; neutrophil chemotaxis; positive regulation of transcription, DNA-templated; positive regulation of protein export from nucleus; positive regulation of prostaglandin secretion; positive regulation of myosin light chain kinase activity; negative regulation of MAP kinase activity; positive regulation of T cell proliferation; positive regulation of interleukin-6 production; inflammatory response; negative regulation of lipid metabolic process; sequestering of triglyceride; hyaluronan biosynthetic process; positive regulation of heterotypic cell-cell adhesion; positive regulation of lipid catabolic process; cellular response to organic cyclic compound; positive regulation of fever generation; positive regulation of DNA-binding transcription factor activity; positive regulation of angiogenesis; response to lipopolysaccharide; positive regulation of NF-kappaB transcription factor activity; positive regulation of granulocyte macrophage colony-stimulating factor production; immune response; ectopic germ cell programmed cell death; leukocyte migration; lipopolysaccharide-mediated signaling pathway; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of cell adhesion molecule production; response to ATP; monocyte aggregation; protein kinase B signaling; positive regulation of nitric oxide biosynthetic process; cell-cell signaling; positive regulation of monocyte chemotactic protein-1 production; regulation of nitric-oxide synthase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of interferon-gamma production; MAPK cascade; positive regulation of histone acetylation; positive regulation of gene expression; negative regulation of glucose transmembrane transport; interleukin-1 beta production; positive regulation of T cell mediated immunity; extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of vascular endothelial growth factor production; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of lipid catabolic process; negative regulation of adiponectin secretion; regulation of establishment of endothelial barrier; positive regulation of cell division; signal transduction; positive regulation of transcription by RNA polymerase II; cytokine-mediated signaling pathway; regulation of defense response to virus by host; fever generation; positive regulation of JNK cascade; positive regulation of cell population proliferation; regulation of signaling receptor activity; positive regulation of epithelial to mesenchymal transition; positive regulation of cell migration; interleukin-6 production; astrocyte activation; regulation of neurogenesis; negative regulation of neurogenesis; negative regulation of synaptic transmission; positive regulation of glial cell proliferation; regulation of ERK1 and ERK2 cascade; interleukin-1-mediated signaling pathway; cellular response to lipopolysaccharide; positive regulation of neuroinflammatory response; positive regulation of p38MAPK cascade; positive regulation of NIK/NF-kappaB signaling; positive regulation of T-helper 1 cell cytokine production; positive regulation of prostaglandin biosynthetic process; positive regulation of complement activation; positive regulation of inflammatory response; response to interleukin-1; positive regulation of RNA biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	3553
	16176
	ENSG00000125538
	ENSMUSG00000027398
	P01584
	P10749
	NM_000576
	NM_008361
	NP_000567
	NP_032387
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene. There are two genes for interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene). IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase) to form mature IL-1β.

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