Interleukin 1-alpha

Interleukin 1-alpha
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ILA, 2KKI, 2L5X
Identifiers
Aliases	IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha, IL-1 alpha, IL-1α
External IDs	OMIM: 147760 MGI: 96542 HomoloGene: 480 GeneCards: IL1A
Gene location (Human)
Chr.	Chromosome 2 (human)
End	112,784,493 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	129,151,892 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; cavity of mouth; ; mucosa of urinary bladder; ; gums; ; islet of Langerhans; ; amniotic fluid; ; gallbladder; ; body of tongue; ; thymus; ; appendix;
	Top expressed in
	esophagus; ; skin of back; ; epidermis; ; cornea; ; spermatocyte; ; liver; ; corneal stroma; ; lip; ; placenta; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; protein binding; copper ion binding; interleukin-1 receptor binding;
Cellular component	cytosol; extracellular region; cytoplasm; extracellular space;
Biological process	cellular response to heat; response to copper ion; positive regulation of angiogenesis; positive regulation of gene expression; immune response; connective tissue replacement involved in inflammatory response wound healing; positive regulation of protein secretion; extrinsic apoptotic signaling pathway in absence of ligand; ectopic germ cell programmed cell death; positive regulation of vascular endothelial growth factor production; cell population proliferation; inflammatory response; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of mitotic nuclear division; positive regulation of cell division; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; apoptotic process; positive regulation of interleukin-6 production; positive regulation of neutrophil extravasation; fever generation; positive regulation of monocyte chemotactic protein-1 production; regulation of signaling receptor activity; cytokine-mediated signaling pathway; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3552
	16175
	ENSG00000115008
	ENSMUSG00000027399
	P01583
	P01582
	NM_000575; NM_001371554
	NM_010554
	NP_000566; NP_001358483
	NP_034684
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL-1α inhibitors are being developed to interrupt those processes and treat diseases.

IL-1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. It is on the pathway that activates tumor necrosis factor-alpha.

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