Insulin-like growth factor 2

Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The MeSH definition reads: "A well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on somatotropin. It is believed to be a major fetal growth factor in contrast to insulin-like growth factor 1 (IGF-1), which is a major growth factor in adults."

IGF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIGF2, C11orf43, GRDF, IGF-II, PP9974, insulin like growth factor 2, SRS3
External IDsOMIM: 147470 MGI: 96434 HomoloGene: 510 GeneCards: IGF2
Orthologs
SpeciesHumanMouse
Entrez

3481

16002

Ensembl

ENSG00000167244

ENSMUSG00000048583

UniProt

P01344

P09535

RefSeq (mRNA)

NM_001291862
NM_000612
NM_001007139
NM_001127598
NM_001291861

NM_001122736
NM_001122737
NM_010514
NM_001315488
NM_001315489

RefSeq (protein)

NP_000603
NP_001007140
NP_001121070
NP_001278790
NP_001278791

NP_001116208
NP_001116209
NP_001302417
NP_001302418
NP_034644

Location (UCSC)Chr 11: 2.13 – 2.16 MbChr 7: 142.2 – 142.22 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse
Insulin-like growth factor II E-peptide (somatomedians-A )
Identifiers
SymbolIGF2_C
PfamPF08365
InterProIPR013576
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
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