IGF2BP2

IGF2BP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQH
Identifiers
Aliases	IGF2BP2, IMP-2, IMP2, VICKZ2, insulin like growth factor 2 mRNA binding protein 2
External IDs	OMIM: 608289 MGI: 1890358 HomoloGene: 4774 GeneCards: IGF2BP2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	185,825,042 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	21,982,049 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; stromal cell of endometrium; ; embryo; ; ganglionic eminence; ; amniotic fluid; ; bronchial epithelial cell; ; right uterine tube; ; rectum; ; retinal pigment epithelium; ; secondary oocyte;
	Top expressed in
	primitive streak; ; medullary collecting duct; ; Paneth cell; ; fossa; ; renal corpuscle; ; condyle; ; abdominal wall; ; external carotid artery; ; internal carotid artery; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	mRNA 5'-UTR binding; protein binding; mRNA binding; translation regulator activity; mRNA 3'-UTR binding; nucleic acid binding; RNA binding;
Cellular component	cytoplasm; cytoskeleton; nucleus; cytosol;
Biological process	anatomical structure morphogenesis; negative regulation of translation; mRNA transport; regulation of translation; regulation of mRNA stability; transport;
	Sources:Amigo / QuickGO
Orthologs
	10644
	319765
	ENSG00000073792
	ENSMUSG00000033581
	Q9Y6M1
	Q5SF07
NM_001007225; NM_001291869; NM_001291872; NM_001291873; NM_001291874;
	NM_001291875; NM_006548
	NM_183029
NP_001007226; NP_001278798; NP_001278801; NP_001278802; NP_001278803;
	NP_001278804; NP_006539
	NP_898850
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene.

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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