IGF2BP1

IGF2BP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KRM
Identifiers
Aliases	IGF2BP1, CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1, insulin like growth factor 2 mRNA binding protein 1
External IDs	OMIM: 608288 MGI: 1890357 HomoloGene: 4772 GeneCards: IGF2BP1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,056,145 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	96,005,940 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; stromal cell of endometrium; ; testicle; ; placenta; ; retinal pigment epithelium; ; kidney; ; kidney; ; renal cortex; ; metanephros; ; thymus;
	Top expressed in
	abdominal wall; ; hand; ; maxillary prominence; ; primitive streak; ; yolk sac; ; endocardial cushion; ; atrium; ; renal corpuscle; ; morula; ; ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	translation regulator activity; mRNA 3'-UTR binding; protein binding; nucleic acid binding; mRNA 5'-UTR binding; mRNA binding; RNA binding;
Cellular component	cytoplasm; CRD-mediated mRNA stability complex; cell projection; filopodium; growth cone; dendritic spine; axon; dendrite; perinuclear region of cytoplasm; cytoplasmic stress granule; nucleus; lamellipodium; nucleoplasm; cytosol; ribonucleoprotein complex;
Biological process	CRD-mediated mRNA stabilization; mRNA transport; negative regulation of translation; pallium cell proliferation in forebrain; neuronal stem cell population maintenance; RNA localization; regulation of translation; regulation of mRNA stability involved in response to stress; regulation of mRNA stability; transport;
	Sources:Amigo / QuickGO
Orthologs
	10642
	140486
	ENSG00000159217
	ENSMUSG00000013415
	Q9NZI8
	O88477
	NM_001160423; NM_006546
	NM_009951
	NP_001153895; NP_006537
	NP_034081; NP_001388383; NP_001388384; NP_001388385; NP_001388386
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.

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