HINT1

HINT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AV5, 1KPA, 1KPB, 1KPC, 1KPE, 1KPF, 3TW2, 4EQE, 4EQG, 4EQH, 4ZKL, 4ZKV, 5I2E, 5I2F
Identifiers
Aliases	HINT1, HINT, NMAN, PKCI-1, PRKCNH1, histidine triad nucleotide binding protein 1
External IDs	OMIM: 601314 MGI: 1321133 HomoloGene: 3904 GeneCards: HINT1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	131,224,468 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	54,761,327 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; oocyte; ; middle temporal gyrus; ; Brodmann area 23; ; pons; ; renal medulla; ; seminal vesicula; ; spinal ganglia; ; germinal epithelium; ; caput epididymis;
	Top expressed in
	fossa; ; renal corpuscle; ; Paneth cell; ; condyle; ; medullary collecting duct; ; facial motor nucleus; ; barrel cortex; ; vas deferens; ; superior cervical ganglion; ; endocardial cushion;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; catalytic activity; hydrolase activity; protein kinase C binding;
Cellular component	histone deacetylase complex; plasma membrane; extracellular exosome; cytoskeleton; nucleus; cytoplasm; cytosol;
Biological process	purine ribonucleotide catabolic process; positive regulation of calcium-mediated signaling; regulation of transcription, DNA-templated; transcription, DNA-templated; intrinsic apoptotic signaling pathway by p53 class mediator; signal transduction; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	3094
	15254
	ENSG00000169567
	ENSMUSG00000020267
	P49773
	P70349
	NM_005340
	NM_008248
	NP_005331
	NP_032274
	Wikidata
View/Edit Human	View/Edit Mouse

Histidine triad nucleotide-binding protein 1 also known as adenosine 5'-monophosphoramidase is an enzyme that in humans is encoded by the HINT1 gene.

HINT1 hydrolyzes purine nucleotide phosphoramidates with a single phosphate group. In addition, functions as scaffolding protein that modulates transcriptional activation.

It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and microphthalmia-associated transcription factor (MITF) activity in human mast cells. In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by diadenosine tetraphosphate (Ap4A), produced by LysRS.

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