GNAL

GNAL
Identifiers
Aliases	GNAL, DYT25, G protein subunit alpha L, HG1O
External IDs	OMIM: 139312 MGI: 95774 HomoloGene: 68222 GeneCards: GNAL
Gene location (Human)
Chr.	Chromosome 18 (human)
End	11,885,685 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	67,359,863 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; middle temporal gyrus; ; nucleus accumbens; ; entorhinal cortex; ; pons; ; superior vestibular nucleus; ; putamen; ; caudate nucleus; ; seminal vesicula; ; parietal lobe;
	Top expressed in
	olfactory tubercle; ; olfactory epithelium; ; nucleus accumbens; ; globus pallidus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; superior frontal gyrus; ; lateral geniculate nucleus; ; medial vestibular nucleus; ; habenula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	guanyl nucleotide binding; nucleotide binding; GTP binding; metal ion binding; G protein-coupled receptor binding; GTPase activity; signal transducer activity; G-protein beta/gamma-subunit complex binding;
Cellular component	plasma membrane; extracellular exosome; heterotrimeric G-protein complex;
Biological process	sensory perception of smell; adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; signal transduction; activation of adenylate cyclase activity; G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2774
	14680
	ENSG00000141404
	ENSMUSG00000024524
	P38405
	Q8CGK7
NM_001142339; NM_001261443; NM_001261444; NM_002071; NM_182978;
	NM_001369387
	NM_010307; NM_177137
	NP_001135811; NP_001248372; NP_001248373; NP_892023; NP_001356316
	NP_034437; NP_796111
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene. Its main product is the heterotrimeric G-protein alpha subunit G_olf-α, a member of the Gs alpha subunit family that is a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways in the olfactory system and the striatum in the brain. It also mediated D1 receptor signalling in the striatum and is hence involved in motor control.

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